A quantitative AOP of mitochondrial toxicity based on data from three cell lines
Cleo Tebby, Wang Gao, Johannes Delp, Giada Carta, Wanda van der Stel, Marcel Leist, Paul Jennings, Bob van de Water, Frederic Y. Bois
Toxicology in Vitro, Volume 81 (2022); DOI: 10.1016/j.tiv.2022.105345
A Novel UPLC-MS Metabolomic Analysis-Based Strategy to Monitor the Course and Extent of iPSC Differentiation to Hepatocytes
Marta Moreno-Torres, Manoj Kumar, Guillem García-Llorens, Guillermo Quintás, Tine Tricot, Ruben Boon, Laia Tolosa, Burak Toprakhisar, Francois Chesnais, Catherine Verfaillie, and José V. Castell
Journal of Proteome Research (2022); DOI: 10.1021/acs.jproteome.1c00779
Specific attenuation of purinergic signaling during bortezomib-induced peripheral neuropathy
Anna-Katharina Holzer, Ilinca Suciu, Thomas Goj, Christiaan Karreman, Marcel Leist
bioRxiv (2022); DOI: 10.1101/2022.02.17.479688
Zebrafish embryo neonicotinoid developmental neurotoxicity in the FET test and behavioral assays
von Hellfeld, Rebecca, Viktoriia Ovcharova, Samantha Bevan, Maria-Agapi Lazaridi, Caroline Bauch, Paul Walker, Susanne Hougaard Bennekou, Anna Forsby, and Thomas Braunbeck.
ALTEX (2022); DOI: 10.14573/altex.2111021
Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling
Dominik Loser, Karin Grillberger, Maria G. Hinojosa, Jonathan Blum, Yves Haufe, Timm Danker, Ylva Johansson, Clemens Möller, Annette Nicke, Susanne H. Bennekou, Iain Gardner, Caroline Bauch, Paul Walker, Anna Forsby, Gerhard F. Ecker, Udo Kraushaar & Marcel Leist
Archives of Toxicology volume 95, pages 3695–3716 (2021); DOI: 10.1007/s00204-021-03168-z
Neurotoxic effects in zebrafish embryos by valproic acid and nine of its analogues: the fish-mouse connection?
Katharina Brotzmann, André Wolterbeek, Dinant Kroese & Thomas Braunbeck
Archives of Toxicology volume 95, pages 641–657 (2021); DOI: 10.1007/s00204-020-02928-7
Neurodevelopmental toxicity assessment of flame retardants using a human DNT in vitro testing battery
Jördis Klose, Melanie Pahl, Kristina Bartmann, Farina Bendt, Jonathan Blum, Xenia Dolde, Nils Förster, Anna-Katharina Holzer, Ulrike Hübenthal, Hagen Eike Keßel, Katharina Koch, Stefan Masjosthusmann, Sabine Schneider, Lynn-Christin Stürzl, Selina Woeste, Andrea Rossi, Adrian Covaci, Mamta Behl, Marcel Leist, Julia Tigges & Ellen Fritsche
Cell Biology and Toxicology (2021);DOI: 10.1007/s10565-021-09603-2
Metabolically Improved Stem Cell Derived Hepatocyte-Like Cells Support HBV Life Cycle and Are a Promising Tool for HBV Studies and Antiviral Drug Screenings
Tricot, Tine, Hendrik J. Thibaut, Kayvan Abbasi, Ruben Boon, Nicky Helsen, Manoj Kumar, Johan Neyts, and Catherine Verfaillie
Biomedecines (2022); DOI: 10.3390/biomedicines10020268
Application of high-throughput transcriptomics for mechanism-based biological read-across of short-chain carboxylic acid analogues of valproic acid
Vrijenhoek, Nanette G., Matthias M. Wehr, Steven J. Kunnen, Lukas S. Wijaya, Giulia Callegaro, Martijn J. Moné, Sylvia E. Escher, and Bob van de Water
ALTEX, 39 (2);DOI: 10.14573/altex.2107261
HiPSC-Derived Hepatocyte-like Cells Can Be Used as a Model for Transcriptomics-Based Study of Chemical Toxicity
Sreya Ghosh, Jonathan De Smedt, Tine Tricot, Susana Proença, Manoj Kumar, Fatemeharefeh Nami, Thomas Vanwelden, Niels Vidal, Paul Jennings, Nynke I. Kramer and Catherine M. Verfaillie
Toxics 2022, 10(1); DOI: 10.3390/toxics10010001
Ten simple rules for creating reusable pathway models for computational analysis and visualization
Kristina Hanspers, Martina Kutmon, Susan L. Coort, Daniela Digles, Lauren J. Dupuis, Friederike Ehrhart, Finterly Hu, Elisson N. Lopes, Marvin Martens, Nhung Pham, Woosub Shin, Denise N. Slenter, Andra Waagmeester, Egon L. Willighagen, Laurent A. Winckers, Chris T. Evelo, Alexander R. Pico
PLoS Comput Biol (2021); DOI: 10.1371/journal.pcbi.1009226
The human hepatocyte TXG-MAPr: gene co-expression network modules to support mechanism-based risk assessment
Wanda van der Stel, Huan Yang, Nanette G. Vrijenhoek, Johannes P. Schimming, Giulia Callegaro, Giada Carta, Salihanur Darici, Johannes Delp, Anna Forsby, Andrew White, Sylvia le Dévédec, Marcel Leist, Paul Jennings, Joost B. Beltman, Bob van de Water & Erik H. J. Danen
Archives of Toxicology volume 96, pages259–285 (2022); DOI: 10.1007/s00204-021-03160-7
The hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds
Tim Brecklinghaus, Wiebke Albrecht, Franziska Kappenberg, Julia Duda, Nachiket Vartak, Karolina Edlund, Rosemarie Marchan, Ahmed Ghallab, Cristina Cadenas, Georgia Günther, Marcel Leist, Mian Zhang, Iain Gardner, Jörg Reinders, Frans GM. Russel, Alison J.Foster, Dominic P. Williams, Amruta Damle-Vartak, Melanie Grandits, Gerhard Ecker, Naim Kittana, Jörg Rahnenführer, Jan G.Hengstler
Chemico-Biological Interactions, Volume 351, 5 January 2022, 109728; DOI: 10.1016/j.cbi.2021.109728
ELIXIR and Toxicology: a community in development
Marvin Martens, Rob Stierum, Emma L. Schymanski, Chris T. Evelo, Reza Aalizadeh, Hristo Aladjov, Kasia Arturi, Karine Audouze, Pavel Babica, Karel Berka, Jos Bessems, Ludek Blaha, Evan E. Bolton, Montserrat Cases, Dimitrios Ε. Damalas, Kirtan Dave, Marco Dilger, Thomas Exner, Daan P. Geerke, Roland Grafström, Alasdair Gray, John M. Hancock, Henner Hollert, Nina Jeliazkova, Danyel Jennen, Fabien Jourdan, Pascal Kahlem, Jana Klanova, Jos Kleinjans, Todor Kondic, Boï Kone, Iseult Lynch, Uko Maran, Sergio Martinez Cuesta, Hervé Ménager, Steffen Neumann, Penny Nymark, Herbert Oberacher, Noelia Ramirez, Sylvie Remy, Philippe Rocca-Serra, Reza M. Salek, Brett Sallach, Susanna-Assunta Sansone, Ferran Sanz, Haralambos Sarimveis, Sirarat Sarntivijai, Tobias Schulze, Jaroslav Slobodnik, Ola Spjuth, Jonathan Tedds, Nikolaos Thomaidis, Ralf J.M. Weber, Gerard J.P. van Westen, Craig E. Wheelock, Antony J. Williams, Hilda Witters, Barbara Zdrazil, Anže Županič51, Egon L. Willighagen
F1000Research 2021, 10(ELIXIR):1129; DOI: 10.12688/f1000research.74502.1
Integrate mechanistic evidence from new approach methodologies (NAMs) into a read-across assessment to characterise trends in shared mode of action
Sylvia E. Escher, Alejandro Aguayo-Orozco, Emilio Benfenati, Annette Bitsch, Thomas Braunbeck, Katharina Brotzmann, Frederic Bois, Bart van der Burg, Jose Castel, Thomas Exner, Domenico Gadaleta, Iain Gardner, Daria Goldmann, Oliver Hatley, Nazanin Golbamaki, Rabea Graepel, Paul Jennings, Alice Limonciel, Anthony Long, Richard Maclennan, Enrico Mombelli, Ulf Norinder, Sankalp Jain, Liliana Santos Capinha, Olivier T. Taboureau, Laia Tolosa, Nanette G.Vrijenhoek, Barbara M.A. van Vugt-Lussenburg, Paul Walker, Bob van de Water, Matthias Wehr, Andrew White, Barbara Zdrazil, Ciarán Fisher
Toxicology in Vitro, Volume 79, March 2022, 105269; DOI: 10.1016/j.tiv.2021.105269
Specificity of time- and dose-dependent morphological endpoints in the fish embryo acute toxicity (FET) test for substances with diverse modes of action: the search for a “fingerprint”
Rebecca von Hellfeld, Pauline Pannetier & Thomas Braunbeck
Environmental Science and Pollution Research volume 29, pages 16176–16192 (2022); DOI: 10.1007/s11356-021-16354-4
Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation
Wanda van der Stel, Huan Yang, Nanette G. Vrijenhoek, Johannes P. Schimming, Giulia Callegaro, Giada Carta, Salihanur Darici, Johannes Delp, Anna Forsby, Andrew White, Sylvia le Dévédec, Marcel Leist, Paul Jennings, Joost B. Beltman, Bob van de Water & Erik H. J. Danen
Archives of Toxicology volume 96, pages 259–285 (2022); DOI: 10.1007/s00204-021-03160-7
Transcriptomic Cross-Species Analysis of Chronic Liver Disease Reveals Consistent Regulation Between Humans and Mice
Christian H. Holland, Ricardo O. Ramirez Flores, Maiju Myllys, Reham Hassan, Karolina Edlund, Ute Hofmann, Rosemarie Marchan, Cristina Cadenas, Jörg Reinders, Stefan Hoehme, Abdel-latif Seddek, Steven Dooley, Verena Keitel, Patricio Godoy, Brigitte Begher-Tibbe, Christian Trautwein, Christian Rupp, Sebastian Mueller, Thomas Longerich, Jan G. Hengstler, Julio Saez-Rodriguez, Ahmed Ghallab
Hepatology Communications (2021); DOI: 10.1002/hep4.1797
A fully defined matrix to support a pluripotent stem cell derived multi-cell-liver steatohepatitis and fibrosis model
Manoj Kumar, Burak Toprakhisar, Matthias Van Haele, Asier Antoranz, Ruben Boon, Francois Chesnais, Jonathan De Smedt, Tine Tricot, Teresa Izuel Idoype, Marco Canella, Pierre Tilliole, Jolan De Boeck, Manmohan Bajaj, Adrian Ranga, Francesca Maria Bosisio, Tania Roskams, Leo A. van Grunsven and Catherine M. Verfaillie
Biomaterials Volume 276, September 2021, 121006; DOI: 10.1016/j.biomaterials.2021.121006
Fluorescent tagging of endogenous Heme oxygenase-1 in human induced pluripotent stem cells for high content imaging of oxidative stress in various differentiated lineages
Kirsten E. Snijders, Anita Fehér, Zsuzsanna Táncos, István Bock, Annamária Téglási, Linda van den Berk, Marije Niemeijer, Peter Bouwman, Sylvia E. Le Dévédec, Martijn J. Moné, Rob Van Rossom, Manoj Kumar, Anja Wilmes, Paul Jennings, Catherine M. Verfaillie, Julianna Kobolák, Bas ter Braak, András Dinnyés & Bob van de Water
Archives of Toxicology volume 95, pages 3285–3302 (2021); DOI: 10.1007/s00204-021-03127-8
Towards an advanced testing strategy for genotoxicity using image-based 2D and 3D HepG2 DNA damage response fluorescent protein reporters
Bas ter Braak, Marije Niemeijer, Liesanne Wolters, Sylvia Le Dévédec, Peter Bouwman, Bob van de Water
Mutagenesis, geab031 (2021); DOI: 10.1093/mutage/geab031
Identifying novel transcript biomarkers for hepatocellular carcinoma (HCC) using RNA-Seq datasets and machine learning
Rajinder Gupta, Jos Kleinjans & Florian Caiment
BMC Cancer 21, 962 (2021); DOI: 10.1186/s12885-021-08704-9
Factors that Influence the Quality of Metabolomics Data in in Vitro Cell Toxicity Studies: A Systematic Survey
Marta Moreno-Torres, Guillem García-Llorens, Erika Moro, Rebeca Méndez, Guillermo Quintás, José Vicente Castell
Research Square (2021); DOI: 10.21203/rs.3.rs-724307/v1
New approach methods supporting read-across: Two neurotoxicity AOP-based IATA case studies
van der Stel, W., Carta, G., Eakins, J., Delp, J., Suciu, I., Forsby, A., Cediel-Ulloa, A., Attoff, K., Troger, F., Kamp, H., Gardner, I., Zdrazil, B., Moné, M. J., Ecker, G. F., Pastor, M., Gómez-Tamayo, J. C., White, A., Danen, E. H. J., Leist, M., Walker, P., Jennings, P., Hougaard Bennekou, S. and van de Water, B.
ALTEX - Alternatives to animal experimentation, 38(4), pp. 615–635 ; DOI: 10.14573/altex.2103051
The in vitro assessment of the toxicity of volatile, oxidisable, redox-cycling compounds: phenols as an example
Laia Tolosa, Teresa Martínez-Sena, Johannes P. Schimming, Erika Moro, Sylvia E. Escher, Bas ter Braak, Bob van der Water, M. A. Miranda, Barbara M. A. van Vugt-Lussenburg & José V. Castell
Archives of Toxicology volume 95, pages2109–2121 (2021); DOI: 10.1007/s00204-021-03036-w
Flame: an open source framework for model development, hosting, and usage in production environments
Manuel Pastor, José Carlos Gómez-Tamayo, Ferran Sanz
Journal of Cheminformatics (2021); DOI : 10.21203/rs.3.rs-107430/v1
Generation and characterization of iPSC-derived renal proximal tubule-like cells with extended stability
Jördis Klose, Melanie Pahl, Kristina Bartmann, Farina Bendt, Jonathan Blum, Xenia Dolde, Nils Förster, Anna-Katharina Holzer, Ulrike Hübenthal, Hagen Eike Keßel, Katharina Koch, Stefan Masjosthusmann, Sabine Schneider, Lynn-Christin Stürzl, Selina Woeste, Andrea Rossi, Adrian Covaci, Mamta Behl, Marcel Leist, Julia Tigges & Ellen Fritsche
Cell Biology and Toxicology (2021); DOI: 10.1038/s41598-021-89550-4
Neurodevelopmental toxicity assessment of flame retardants using a human DNT in vitro testing battery
Jördis Klose, Melanie Pahl, Kristina Bartmann, Farina Bendt, Jonathan Blum, Xenia Dolde, Nils Förster, Anna-Katharina Holzer, Ulrike Hübenthal, Hagen Eike Keßel, Katharina Koch, Stefan Masjosthusmann, Sabine Schneider, Lynn-Christin Stürzl, Selina Woeste, Andrea Rossi, Adrian Covaci, Mamta Behl, Marcel Leist, Julia Tigges & Ellen Fritsche
Cell Biology and Toxicology (2021) ; DOI: 10.1007/s10565-021-09603-2
Stimulation of de novo glutathione synthesis by nitrofurantoin for enhanced resilience of hepatocytes
Lukas S. Wijaya, Carina Rau, Theresa S. Braun, Serif Marangoz, Vincent Spegg, Matthijs Vlasveld, Wiebke Albrecht, Tim Brecklinghaus, Hennicke Kamp, Joost B. Beltman, Jan G. Hengstler, Bob van de Water, Marcel Leist & Stefan Schildknecht
Cell Biology and Toxicology (2021) ; DOI: 10.1007/s10565-021-09610-3
Directed differentiation of human induced pluripotent stem cells to hepatic stellate cells
Julia Vallverdú, Raquel A. Martínez García de la Torre, Inge Mannaerts, Stefaan Verhulst, Ayla Smout, Mar Coll, Silvia Ariño, Teresa Rubio-Tomás, Beatriz Aguilar-Bravo, Celia Martínez-Sánchez, Delia Blaya, Catherine M. Verfaillie, Leo A. van Grunsven & Pau Sancho-Bru
Nature Protocols volume 16, pages 2542–2563 (2021); DOI : 10.1038/s41596-021-00509-1
Integration of temporal single cell cellular stress response activity with logic-ODE modeling reveals activation of ATF4-CHOP axis as a critical predictor of drug-induced liver injury
Lukas Surya Wijayaa , Panuwat Trairatphisan, Attila Gabor, Marije Niemeijera, Jason Keet, Ariadna Alcalà Morera, Kirsten E. Snijders, Steven Wink, Huan Yang, Stefan Schildknecht, James L. Stevens, Peter Bouwman, Hennicke Kamp, Jan Hengstler, Joost Beltman, Marcel Leist, Sylvia Le Dévédec, Julio Saez-Rodriguez, Bob van de Water
Biochemical Pharmacology Volume 190, 114591 (August 2021); DOI: 10.1016/j.bcp.2021.114591
A human stem cell-derived test system for agents modifying neuronal N-methyl-D-aspartate-type glutamate receptor Ca2+-signalling
Stefanie Klima, Markus Brüll, Anna-Sophie Spreng, Ilinca Suciu, Tjalda Falt, Jens C. Schwamborn, Tanja Waldmann, Christiaan Karreman & Marcel Leist
Arch Toxicol 95, 1703–1722 (2021); DOI: 10.1007/s00204-021-03024-0
Physiologically Relevant Estrogen Receptor Alpha Pathway Reporters for Single-Cell Imaging-Based Carcinogenic Hazard Assessment of Estrogenic Compounds
Britt Duijndam, Annabel Goudriaan, Tineke van den Hoorn, Wanda van der Stel, Sylvia Le Dévédec, Peter Bouwman, Jan Willem van der Laan, Bob van de Water
Toxicological Sciences, Volume 181, Issue 2, June 2021, Pages 187–198; DOI: 10.1093/toxsci/kfab037
Systematic transcriptome-based comparison of cellular adaptive stress response activation networks in hepatic stem cell-derived progeny and primary human hepatocytes
Bas ter Braak, Marije Niemeijer, Ruben Boon, Céline Parmentier, Audrey Baze, Lysiane Richert, Suzanna Huppelschoten, Steven Wink, Catherine Verfaillie, Bob van de Water
Toxicology in Vitro, Volume 73 (June 2021), Article 105107; doi: 10.1016/j.tiv.2021.105107
Functional alterations by a subgroup of neonicotinoid pesticides in human dopaminergic neurons
Dominik Loser, Maria G. Hinojosa, Jonathan Blum, Jasmin Schaefer, Markus Brüll, Ylva Johansson, Ilinca Suciu, Karin Grillberger, Timm Danker, Clemens Möller, Iain Gardner, Gerhard F. Ecker, Susanne H. Bennekou, Anna Forsby, Udo Kraushaar & Marcel Leist
Arch Toxicol 95, 2081-2107 (2021); DOI: 10.1007/s00204-021-03031-1
Effective exposure of chemicals in in vitro cell systems: A review of chemical distribution models
Susana Proença, Beate I. Escher, Fabian C. Fischer, Ciarán Fisher, Sébastien Grégoire, Nicky J. Hewitt, Beate Nicol, Alicia Paini, Nynke I. Kramera
Toxicology Letters; doi: 10.1016/j.tiv.2021.105133
A quantitative in vivo assay for craniofacial developmental toxicity of histone deacetylases
Bjoern Koch, Annamarie Meijer and Herman Spaink
Toxicology Letters; doi: 10.1016/j.toxlet.2021.02.005
Combining In Vivo Data with In Silico Predictions for Modeling Hepatic Steatosis by Using Stratified Bagging and Conformal Prediction
Sankalp Jain, Ulf Norinder, Sylvia E. Escher, and Barbara Zdrazil
Chem. Res. Toxicol. 2020, DOI: 10.1021/acs.chemrestox.0c00511
Adverse effects in the fish embryo acute toxicity (FET) test: a catalogue of unspecific morphological changes versus more specific effects in zebrafish (Danio rerio) embryos
Rebecca von Hellfeld, Katharina Brotzmann, Lisa Baumann, Ruben Strecker & Thomas Braunbeck
Environ Sci Eur 32, 122 (2020). https://doi.org/10.1186/s12302-020-00398-3
Setting the stage for next-generation risk assessment with non-animal approaches: the EU-ToxRisk project experience
M. J. Moné, G. Pallocca, S. E. Escher, T. Exner, M. Herzler, S. Hougaard Bennekou, H. Kamp, E. D. Kroese, Marcel Leist, T. Steger-Hartmann & B. van de Water
Arch Toxicol 94, 3581–3592 (2020). DOI 10.1007/s00204-020-02866-4
A read-across study on diketones.
Kühne, B., Ritter, D., Knebel, J., Boei, J., Vrieling, H., Hiemstra, P., Escher, S., Hansen, T.
The Toxicologist Supplement to Toxicological Sciences, 168 (1), 243
ATF6 Is a Critical Determinant of CHOP Dynamics during the Unfolded Protein Response
Yang H, Niemeijer M, van de Water B, Beltman JB
iScience, Vol 23, Issue 2, DOI 10.1016/j.isci.2020.100860
Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease .
Campos, G., Schmidt-Heck, W., De Smedt, J., Widera, A., Ghallab, A., Puetter, L., Gonzalez, D., Edlund, K., Cadenas, C., Marchan, R., Guthke, R., Verfaillie, C., Hetz, C., Sachinidis, A., Braeuning, A., Schwarz, M., Weiss, T.S., Banhart, B.K., Hoek, J., Vadigepalli, R., Willy, J., Stevens, J.L., Hay, D.C., Hengstler, J.G., Godoy, P.
Arch Toxicol, Vol 94, Pages 205-217, DOI 10.1007/s00204-019-02630-3
The exposome – a new approach for risk assessment
Sillé FCM, Karakitsios S, Kleensang A, Koehler K, Maertens A, Miller GW, Prasse C, Quiros-Alcala L, Ramachandran G, Rappaport SM, Rule AM, Sarigiannis D, Smirnova L and Hartung T
ALTEX, Vol 37, Issue 1, Pages 3-23, DOI 10.14573/altex.2001051
Evaluation of the global performance of eight in silico skin sensitization models using human data
Golden E, Macmillan DS, Dameron G, Kern P, Hartung T and Maertens A
ALTEX (2020), DOI 10.14573/altex.1911261
Using Machine Learning Methods and Structural Alerts for Prediction of Mitochondrial Toxicity
J. Hemmerich, F. Troger, B. Füzi, G. F. Ecker
Molecular Informatics, Vol 39, Issue 5, DOI 10.1002/minf.202000005
Identification of mitochondrial toxicants by combined in silico and in vitro studies – A structure-based view on the adverse outcome pathway
F. Troger, J. Delp, M. Funke, W. van der Stel, C. Colas, M. Leist, B. van de Water, G. F. Ecker
Computational Toxicology, Vol 14, Pages 100-123, DOI 10.1016/j.comtox.2020.100123
Development of a generic zebrafish embryo PBPK model and application to the developmental toxicity assessment of valproic acid analogs
Simeon S., Brotzmann K., Fisher C., Gardner I., Silvester S., Maclennan R., Walker P., Braunbeck T., Bois F.
Reproductive Toxicology, Vol 93, Pages 219-229, DOI 10.1016/j.reprotox.2020.02.010
Investigation of Nrf2, AhR and ATF4 activation in toxicogenomic databases
Zgheib E., Limonciel A., Jiang X., Wilmes A., Wink S., van de Water B., Kopp-Schneider A., Bois F., Jennings P
Frontiers in Genetics (2018), DOI 10.3389/fgene.2018.00429
sAOP: linking chemical stressors to adverse outcome pathway networks
Aguayo-Orozco A. Audouze K. Siggaard T. Barouki R. Brunak S. Taboureau O.
Bioinformatics, Vol 35, Issue 24, Pages 5391-5392, DOI10.1093/bioinformatics/btz570
The use of systems biology in chemical risk assessment.
Aguayo-Orozco A. Taboureau O. Brunak S.
Current opinion in toxicology, Vol 15, Pages 48-54, doi.org/10.1016/j.cotox.2019.03.003
Time- and space-resolved quantification of plasma membrane sialylation for measurements of cell function and neurotoxicity
Kranaster P, Karreman C, Dold JEGA, Krebs A, Funke M, Holzer AK, Nyffeler J, Helfrich S, Wittmann V, Leist M
Arch Toxicol, Vol 94, Issue 2, Pages 449-467, DOI 10.1007/s00204-019-02642-z
Incorporation of stem cell-derived astrocytes into neuronal organoids to allow neuro-glial interactions in toxicological studies
Brüll M, Spreng AS, Gutbier S, Loser D, Krebs A, Reich M, Kraushaar U, Britschgi M, Patsch C, Leist M
ALTEX, Vol 37, Issue 3, DOI 10.14573/altex.1911111
Design and evaluation of bi-functional iron chelators for protection of dopaminergic neurons from toxicants
Gutbier S, Kyriakou S, Schildknecht S, Ückert AK, Brüll M, Lewis F, Dickens D, Pearson L, Elson JL, Michel S, Hubscher-Bruder V, Brandel J, Tetard D, Leist M, Pienaar IS
Arch Toxicol; 2020
Human Induced Pluripotent Stem Cell-Derived 3D-Neurospheres Are Suitable for Neurotoxicity Screening
Kobolak, J.; Teglasi, A.; Bellak, T.; Janstova, Z.; Molnar, K.; Zana, M.; Bock, I.; Laszlo, L.; Dinnyes, A.
Cells; Vol 9, Issue 5, Page 1122, DOI 10.3390/cells9051122
The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods
Alice Krebs, Barbara M. A. van Vugt-Lussenburg, Tanja Waldmann, Wiebke Albrecht, Jan Boei, Bas ter Braak, Maja Brajnik, Thomas Braunbeck, Tim Brecklinghaus, Francois Busquet, Andras Dinnyes, Joh Dokler, Xenia Dolde, Thomas Exner, Ciarán Fisher, David Fluri, Anna Forsby, Jan Hengstler, Anna-Katharina Holzer, Zofia Janstova, Paul Jennings, Jaffar Kisitu, Julianna Kobolak, Manoj Kumar, Alice Limonciel, Jessica Lundqvist, Balázs Mihalik, Wolfgang Moritz, Giorgia Pallocca, Andrea Paola Cedie Ulloa, Manuel Pastor, Costanza Rovida, Ugis Sarkans, Johannes P Schimming, Bela Z Schmidt, Regina Stöber, Tobias Strassfeld, Bob van de Water, Anja Wilmes, Bart van der Burg, Catherine Verfaille, Rebecca von Hellfeld, Harry Vrieling, Nanette G. Vrijenhoek and Marcel Leist.
Arch. Toxicol; Vol 94, Pages 2435–2461, DOI 10.1007/s00204-020-02802-6
Harnessing the power of novel animal-free test methods for the development of COVID-19 drugs and vaccines
Busquet F., Hartung T., Pallocca G., Rovida C., Leist M.
Arch. Toxicol; Vol 94, Issue 6, Pages 2263-2272, DOI 10.1007/s00204-020-02787-2
Internationalization of read-across as a validated new approach method (NAM) for regulatory toxicology
Rovida C., Barton-Maclaren T, Benfenati E, Caloni F, Chandrasekera C, Chesne C, Cronin MTD, De Knecht J, Dietrich DR, Escher SE, Fitzpatrick S, Flannery B, Herzler M, Hougaard Bennekou S, Hubesch B, Kamp H, Kisitu J, Kleinstreuer N, Kovarich S, Leist M, Maertens A, Nugent K, Pallocca G, Pastor M, Patlewicz G, Pavan M, Presgrave O, Smirnova L, Schwarz M, Yamada T, Hartung T
ALTEX, 2020, DOI 10.14573/altex.1912181
Biology-inspired Microphysiological systems to advance patient benefit and animal welfare in drug development
Marx U, Takafumi Akabane, Tommy B Andersson, Elizabeth Baker, Mario Beilmann, Sonja Beken, Susanne Brendler-Schwaab, Murat Cirit, Rhiannon David, Eva-Maria Dehne, Isabell Durieux, Lorna Ewart, Suzanne C Fitzpatrick, Olivier Frey , Florian Fuchs, Linda G Griffith, Geraldine A Hamilton, Thomas Hartung, Julia Hoeng , Helena Hogberg, David J Hughes, Donald E Ingber, Anita Iskandar, Toshiyuki Kanamori, Hajime Kojima, Jochen Kuehnl, Marcel Leist, Bo Li, Peter Loskill, Donna L Mendrick, Thomas Neumann, Giorgia Pallocca, Ivan Rusyn, Lena Smirnova , Thomas Steger-Hartmann, Danilo A Tagle, Alexander Tonevitsky, Sergej Tsyb , Martin Trapecar, Bob Van de Water, Janny Van den Eijnden-van Raaij, Paul Vulto, Kengo Watanabe, Armin Wolf, Xiaobing Zhou, Adrian Roth
ALTEX, Vol 37, Issue 3, DOI 10.14573/altex.2001241
Determination of benchmark concentrations and their statistical uncertainty for cytotoxicity test data and functional in vitro assays
Krebs A, Nyffeler J, Karreman C, Schmidt BZ, Kappenberg F, Mellert J, Pallocca G, Pastor M, Rahnenführer J, Leist M.
ALTEX, Vol 37, Issue 1, Pages 155-163, DOI 10.14573/altex.1912021
Multiparametric assessment of mitochondrial respiratory inhibition in HepG2 and RPTEC/TERT1 cells using a panel of mitochondrial targeting agrochemicals
Van der Stel et al.
Arch. Toxicol, Vol 94, Issue 8, Pages 1-23, DOI 10.1007/s00204-020-02792-5
Automated integration of structural, biological and metabolic similarities to sustain read-across
Domenico Gadaleta, Azadi Golbamaki Bakhtyari, Giovanna Janet Lavado, Alessandra Roncaglioni, Emilio Benfenati
ALTEX, Vol 37, Issue 3, DOI 10.14573/altex.2002281
Road map for development of stem cell-based alternative test methods.
Agapios Sachinidis, Wiebke Albrecht, Patrick Nell, Anna Cherianidou, Nicola J. Hewitt, Karolina Edlund, Jan G. Hengstler
Trends in Molecular Medicine, Volume 25, Issue 6, June 2019, Pages 470-481
Structure learning of Bayesian networks involving cyclic structures
Witold Wiecek, Frederic Y. Bois, Ghislaine Gayraud
HAL Archives
Benfenati E, Chaudhry Q, Gini G, Dorne JL
Environ Int. 2019 Oct;131:105060. doi: 10.1016/j.envint.2019.105060
Towards grouping concepts based on new approach methodologies in chemical hazard assessment: the read-across approach of the EU-ToxRisk project
Escher, S.E., Kamp, H., Bennekou, S.H. et al.
Arch Toxicol (2019) 93: 3643. https://doi.org/10.1007/s00204-019-02591-7
Analysis of Time-Series Gene Expression Data to Explore Mechanisms of Chemical-Induced Hepatic Steatosis Toxicity
Aguayo-Orozco A, Bois FY, Brunak S and Taboureau O
Front. Genet. 9:396. doi: 10.3389/fgene.2018.00396
Optimizing drug discovery by Investigative Toxicology: Current and future trends
Beilmann, M., Boonen, H., Czich, A., Dear, G., Hewitt, P., Mow, T., Newham, P., Oinonen, T., Pognan, F., Roth, A., Valentin, J.-P., Van Goethem, F., Weaver, R., Birk, B., Boyer, S., Caloni, F., Chen, A., Corvi, R., Cronin, M., Daneshian, M., Ewart, L., Fitzgerald, R., Hamilton, G., Hartung, T., Kangas, J., Kramer, N., Leist, M., Marx, U., Polak, S., Rovida, C., Testai, E., van der Water, B., Vulto, P. and Steger-Hartmann, T.
ALTEX - Alternatives to animal experimentation, 36(2), pp. 289-313. doi: 10.14573/altex.1808181.
A systematic analysis of Nrf2 pathway activation dynamics during repeated xenobiotic exposure
Bischoff, L.J.M., Kuijper, I.A., Schimming, J.P. et al.
Arch Toxicol (2019) 93: 435. https://doi.org/10.1007/s00204-018-2353-2
Bopp SK, Barouki R, Brack W, Dalla Costa S, Dorne JCM, Drakvik PE, Faust M, Karjalainen TK, Kephalopoulos S, van Klaveren J, Kolossa-Gehring M, Kortenkamp A, Lebret E, Lettieri T, Nørager S, Rüegg J, Tarazona JV, Trier X, van de Water B, van Gils J, Bergman Å
Environ Int. 2018 Nov;120:544-562. doi: 10.1016/j.envint.2018.07.037
Regulatory Acceptance of Read-Across
Chesnut, M., Yamada, T., Adams, T., Knight, D., Kleinstreuer, N., Kass, G., Luechtefeld, T., Hartung, T. and Maertens, A.
ALTEX - Alternatives to animal experimentation, 35(3), pp. 413-419. doi: 10.14573/altex.1805081
Characterisation of the Nrf2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury
Copple, I.M., den Hollander, W., Callegaro, G. et al.
Arch Toxicol (2019) 93: 385. https://doi.org/10.1007/s00204-018-2354-1
Computational Toxicology: Risk Assessment for Chemicals_Computational Toxicology and Reach
Ekins, S., Benfenati, Anna Lombardo, and Alessandra Roncaglioni
Chapter in Computational Toxicology: Risk Assessment for Chemicals_Computational Toxicology and Reach, ISBN: 978-1-119-28256-3
Grinberg M, Stöber RM, Albrecht W, Edlund K, Schug M, Godoy P, Cadenas C, Marchan R, Lampen A, Braeuning A, Buhrke T, Leist M, Oberemm A, Hellwig B, Kamp H, Gardner I, Escher S, Taboureau O, Aguayo-Orozco A, Sachinidis A, Ellinger-Ziegelbauer H, Rahnenführer J, Hengstler JG
Arch Toxicol. 2018 Dec;92(12):3517-3533. doi: 10.1007/s00204-018-2352-3.
Prevention of neuronal apoptosis by astrocytes through thiol-mediated stress response modulation and accelerated recovery from proteotoxic stress
Gutbier, S., Spreng, A., Delp, J. et al.
Cell Death Differ 25, 2101–2117 (2018) doi:10.1038/s41418-018-0229-x
Toxicity, recovery, and resilience in a 3D dopaminergic neuronal in vitro model exposed to rotenone
Harris, G., Eschment, M., Orozco, S.P. et al.
Arch Toxicol (2018) 92: 2587. https://doi.org/10.1007/s00204-018-2250-8
Essential Components of Methods Papers
Leist, M. and Hengstler, J.
ALTEX - Alternatives to animal experimentation, 35(3), pp. 429-432. doi: 10.14573/altex.1807031
Machine Learning of Toxicological Big Data Enables Read-Across Structure Activity Relationships (RASAR) Outperforming Animal Test Reproducibility
Thomas Luechtefeld, Dan Marsh, Craig Rowlands, Thomas Hartung
Toxicological Sciences, Volume 165, Issue 1, September 2018, Pages 198–212,
Oppelt A, Kaschek D, Huppelschoten S, Sison-Young R, Zhang F, Buck-Wiese M, Herrmann F, Malkusch S, Krüger CL, Meub M, Merkt B, Zimmermann L1 Schofield A, Jones RP, Malik H, Schilling M, Heilemann M, van de Water B3 Goldring CE, Park BK, Timmer J, Klingmüller
NPJ Syst Biol Appl. 2018 Jun 11;4:23. doi: 10.1038/s41540-018-0058-z
Advanced Good Cell Culture Practice for Human Primary, Stem Cell-Derived and Organoid Models as well as Microphysiological Systems
Pamies, D., Bal-Price, A., Chesné, C., Coecke, S., Dinnyes, A., Eskes, C., Grillari, R., Gstraunthaler, G., Hartung, T., Jennings, P., Leist, M., Martin, U., Passier, R., Schwamborn, J., Stacey, G., Ellinger-Ziegelbauer, H. and Daneshian, M
ALTEX - Alternatives to animal experimentation, 35(3), pp. 353-378. doi: 10.14573/altex.1710081.
The BioStudies database—one stop shop for all data supporting a life sciences study
Ugis Sarkans, Mikhail Gostev, Awais Athar, Ehsan Behrangi, Olga Melnichuk, Ahmed Ali, Jasmine Minguet, Juan Camillo Rada, Catherine Snow, Andrew Tikhonov, Alvis Brazma, Johanna McEntyre ,
Nucleic Acids Research, Volume 46, Issue D1, 4 January 2018, Pages D1266–D1270,
Spatio-temporal visualization of the distribution of acetaminophen as well as its metabolites and adducts in mouse livers by MALDI MSI
Selahaddin Sezgin, Reham Hassan, Sebastian Zühlke, Lars Kuepfer, Jan G. Hengstler, Michael Spiteller, Ahmed Ghallab
Arch Toxicol (2018) 92: 2963. https://doi.org/10.1007/s00204-018-2271-3
An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition
Terron, A., Bal-Price, A., Paini, A. et al.
Arch Toxicol (2018) 92: 41. https://doi.org/10.1007/s00204-017-2133-4
Toma C, Gadaleta D, Roncaglioni A, Toropov A, Toropova A, Marzo M, Benfenati E.
Pharm Res. 2018 Dec 27;36(2):28. doi: 10.1007/s11095-018-2561-8.
Application of three approaches for quantitative AOP development to renal toxicity
Elias Zgheib, Wang Gao, Alice Limonciel, Hristo Aladjov, Huan Yang, Cleo Tebby, Ghislaine Gayraud, Paul Jennings, Magdalini Sachana, Joost B. Beltman, Frederic Y. Bois
Computational Toxicology. Volume 11, August 2019, Pages 1-13
Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations
Albrecht, W., Kappenberg, F., Brecklinghaus, T. et al.
Arch Toxicol (2019) 93: 1609.
Johannes Delp, Melina Funke, Franziska Rudolf, Andrea Cediel, Susanne Hougaard Bennekou, Wanda van der Stel, Giada Carta, Paul Jennings, Cosimo Toma, Iain Gardner, Bob van de Water, Anna Forsby, Marcel Leist
Arch Toxicol (2019) 93: 1585. doi.org/10.1007/s00204-019-02473-y
Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood.
Ghallab, A., Hofmann, U., Sezgin, S., Vartak, N., Hassan, R., Zaza, A., Godoy, P., Schneider, K.M., Guenther, G., Ahmed, Y.A., Abbas, A.A., Keitel, V., Kuepfer, L., Dooley, S., Lammert, F., Trautwein, C., Spiteller, M., Drasdo, D., Hofmann, A.F., Jansen, P.L., Hengstler, J.G. and Reif, R.
Hepatology, 69: 666-683. doi:10.1002/hep.30213
Paradigm shift in safety assessment using new approach methods: The EU-ToxRisk strategy
R. Graepel, B. Ter Braak, S.E. Escher, C. Fisher, I. Gardner, H. Kamp, D. Kroese, M. Leist, M.J. Moné, M. Pastor, B. van de Water
Current Opinion in Toxicology, Volume 15, June 2019, Pages 33-39
Chemical Concentrations in Cell Culture Compartments (C5) – Concentration Definitions
Kisitu, J., Hougaard Bennekou, S. and Leist, M
ALTEX - Alternatives to animal experimentation, 36(1), pp. 154-160. doi: 10.14573/altex.1901031.
Schimming JP, Ter Braak B, Niemeijer M, Wink S, van de Water B
Methods Mol Biol. 2019;1981:187-202. doi: 10.1007/978-1-4939-9420-5_13.
Integrating in silico models and read-across methods for predicting toxicity of chemicals: A step-wise strategy
Emilio Benfenati, Qasim Chaudhry, Giuseppina Gini, Jean Lou Dorne
Environment International. Volume 131, October 2019, 105060
SUIKER: Quantification of antigens in cell organelles, neurites and cellular sub-structures by imaging
Karreman, C., Kranaster, P. and Leist, M.
ALTEX - Alternatives to animal experimentation, 36(3), pp. 518-520. doi: 10.14573/altex.1906251.
Finding synergies for the 3Rs – Repeated Dose Toxicity testing: Report from an EPAA Partners' Forum
van de Water B.
Regulatory Toxicology and Pharmacology, Volume 108, November 2019, 104470
Sachinidis A, Albrecht W, Nell P, Cherianidou A, Hewitt NJ, Edlund K, Hengstler JG.
Trends Mol Med. 2019 Jun;25(6):470-481. doi: 10.1016/j.molmed.2019.04.003.
Autologous induced pluripotent stem cell-derived four-organ-chip
Anja Patricia Ramme, Leopold Koenig, Tobias Hasenberg, Christine Schwenk, Corinna Magauer, Daniel Faust, Alexandra K Lorenz, Anna-Catharina Krebs, Christopher Drewell, Kerstin Schirrmann, Alexandra Vladetic, Grace-Chiaen Lin, Stephan Pabinger, Winfried Neuhaus, Frederic Bois, Roland Lauster, Uwe Marx & Eva-Maria Dehne
Future Science OA, Vol. 5, No. 8. 2019. 10.2144/fsoa-2019-0065
Predicting toxicity of chemicals: software beats animal testing
T. Hartung
EFSA Journal. Volume 17, Issue S1. 2019. 10.2903/j.efsa.2019.e170710
High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability
Hiemstra S, Ramaiahgari SC, Wink S, Callegaro G, Coonen M, Meerman J, Jennen D, van den Nieuwendijk K, Dankers A, Snoeys J, de Bont H, Price L, van de Water B
Arch Toxicol. 2019 Oct;93(10):2895-2911. doi: 10.1007/s00204-019-02552-0
Template for the Description of Cell-Based Toxicological Test Methods to Allow Evaluation and Regulatory Use of the Data
Bart van der Burg, Andrea Terron, Thomas Steger-Hartmann, Costanza Rovida, Hennicke Kamp, Matthias Herzler, Jan G. Hengstler, Tuula Heinonen, Thomas Hartung, Barry Hardy, Tomas Exner, Francois Busquet, Bennekou S. H., Beilmann M. and Leist M.
ALTEX - Alternatives to animal experimentation, 36(4), pp. 682-699. doi: 10.14573/altex.1909271.
Development of a neural rosette formation assay (RoFA) to identify neurodevelopmental toxicants and to characterize their transcriptome disturbances
Nadine Dreser, Katrin Madjar, Anna-Katharina Holzer, Marion Kapitza, Christopher Scholz, Petra Kranaster, Simon Gutbier, Stefanie Klima, David Kolb, Christian Dietz, Timo Trefzer, Johannes Meisig, Christoph van Thriel, Margit Henry, Michael R. Berthold, Nils Blüthgen, Agapios Sachinidis, Jörg Rahnenführer, Jan G. Hengstler, Tanja Waldmann, Marcel Leist
Arch Toxicol (2019). pp 1–21. 10.1007/s00204-019-02612-5
Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment
Bennekou SH, van der Burg B, van de Water B
Volume 134, January 2020, 105267. 10.1016/j.envint.2019.105267
Introducing WikiPathways as a Data-Source to Support Adverse Outcome Pathways for Regulatory Risk Assessment of Chemicals and Nanomaterials
Marvin Martens, Tim Verbruggen, Penny Nymark, Roland Grafström, Lyle D. Burgoon, Hristo Aladjov, Fernando Torres Andón, Chris T. Evelo and Egon L. Willighagen
Front. Genet., 21 December 2018, doi: 10.3389/fgene.2018.00661
VIVD: Virtual in vitro distribution model for the mechanistic prediction of intracellular concentrations of chemicals in in vitro toxicity assays
Fisher, C., Siméon, S., Jamei, M., Gardner, I., Bois, Y.F.
Toxicology in Vitro, December 2018,DOI:10.1016/j.tiv.2018.12.017
Persistence of Epigenomic Effects After Recovery From Repeated Treatment With Two Nephrocarcinogens.
Limonciel A, van Breda SG, Jiang X, Tredwell GD, Wilmes A, Aschauer L, Siskos AP, Sachinidis A, Keun HC, Kopp-Schneider A, de Kok TM, Kleinjans JCS, Jennings P1.
Front Genet. 2018 Dec 3;9:558. doi: 10.3389/fgene.2018.00558. eCollection 2018.
A new semi-automated workflow for chemical data retrieval and quality checking for modeling applications
Domenico Gadaleta, Anna Lombardo, Cosimo Toma, Emilio Benfenati
Journal of Cheminformatics 201810:60, doi.org/10.1186/s13321-018-0315-6
Major changes of cell function and toxicant sensitivity in cultured cells undergoing mild, quasi-natural genetic drift
Gutbier, S., May, P., Berthelot, S. et al.
Arch Toxicol. 2018 Oct 8, DOI: 10.1007/s00204-018-2326-5
Development of an Infrastructure for the Prediction of Biological Endpoints in Industrial Environments. Lessons Learned at the eTOX Project
Pastor M, Quintana J and Sanz F
Front. Pharmacol., 11 October 2018, DOI: 10.3389/fphar.2018.01147
Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes
Xiaolong Gu, · Wiebke Albrecht, · Karolina Edlund · Franziska Kappenberg, · Jörg Rahnenführer, · Marcel Leist, · Wolfgang Moritz, · Patricio Godoy, · Cristina Cadenas, · Rosemarie Marchan, · Tim Brecklinghaus · Laia Tolosa Pardo6 · José V. Castell6 · Iain Gardner7 · Bo Han2 · Jan G. Hengstler1 · Regina Stoeber1
Arch Toxicol. 2018 Oct 13, DOI: 10.1007/s00204-018-2302-0
QSAR Modeling of ToxCast Assays Relevant to the Molecular Initiating Events of AOPs Leading to Hepatic Steatosis
Gadaleta D., Manganelli S., Roncaglioni A., Toma C., Benfenati E., Mombelli E.
J. Chem. Inf. Model. 58, 8, 1501-1517; DOI: 10.1021/acs.jcim.8b00297
Alice Limonciel, Gamze Ates, Giada Carta, Anja Wilmes, Manfred Watzele, Peter J. Shepard, Harper C. VanSteenhouse, Bruce Seligmann, Joanne M. Yeakley, Bob van de Water, Mathieu Vinken Email, Paul Jennings
Limonciel, A., Ates, G., Carta, G. et al. Arch Toxicol (2018). https://doi.org/10.1007/s00204-018-2256-2
Generation of Hepatic Stellate Cells from Human Pluripotent Stem Cells Enables In Vitro Modeling of Liver Fibrosis
Mar Coll, Luis Perea, Ruben Boon, Sofia B. Leite, Julia Vallverdú, Inge Mannaerts, Ayla Smout, Adil El Taghdouini, Delia Blaya, Daniel Rodrigo-Torres, Isabel Graupera, Beatriz Aguilar-Bravo, Christophe Chesne, Mustapha Najimi, Etienne Sokal, Juan José Lozano, Leo A. van Grunsven, Catherine M. Verfaillie, Pau Sancho-Bru
Cell Stem Cell (2018), https://doi.org/10.1016/j.stem.2018.05.027
Comparing the performance of meta-classifiers-a case study on selected imbalanced data sets relevant for prediction of liver toxicity.
Jain S., Kotsampasakou E., Ecker G. F.
J Comput Aided Mol Des. 2018 May;32(5):583-590. doi: 10.1007/s10822-018-0116-z. Epub 2018 Apr 6. PMID: 29626291 [PubMed - in process] Free PMC Article
Insights into the Structure, Function, and Ligand Discovery of the Large Neutral Amino Acid Transporter 1, LAT1.
Singh N., Ecker G. F.
Int J Mol Sci. 2018 Apr 24;19(5). pii: E1278. doi: 10.3390/ijms19051278. Review. PMID: 29695141 [PubMed - in process] Free PMC Article
Predicting drug resistance related to ABC transporters using unsupervised Consensus Self-Organizing Maps.
Estrada-Tejedor R., Ecker G. F..
Sci Rep. 2018 May 1;8(1):6803. doi: 10.1038/s41598-018-25235-9. PMID: 29717183 [PubMed - in process] Free Article
Human Environmental Disease Network: A computational model to assess toxicology of contaminants.
Taboureau O, Audouze K.
ALTEX. 2017;34(2):289-300. doi: 10.14573/altex.1607201. Epub 2016 Oct 21. PMID: 27768803 [PubMed - indexed for MEDLINE]
A systems biology approach to predictive developmental neurotoxicity of a larvicide used in the prevention of Zika virus transmission.
Audouze K., Taboureau O., Grandjean P..
Toxicol Appl Pharmacol. 2018 Feb 21. pii: S0041-008X(18)30060-7. doi: 10.1016/j.taap.2018.02.014. [Epub ahead of print] PMID: 29476864 [PubMed - as supplied by publisher]
DTNI: a novel toxicogenomics data analysis tool for identifying the molecular mechanisms underlying the adverse effects of toxic compounds.
Hendrickx D. M., Souza T., Jennen D. G. J., Kleinjans J. C. S.
Arch Toxicol. 2017 Jun;91(6):2343-2352. doi: 10.1007/s00204-016-1922-5. Epub 2016 Dec 28. PMID: 28032149 [PubMed - indexed for MEDLINE] Free PMC Article
Validation of gene expression profiles from cholestatic hepatotoxicants in vitro against human in vivo cholestasis.
Van den Hof W. F. P. M., Coonen M. L. J., van Herwijnen M., Brauers K., Jennen D., Olde Damink S. W. M., Schaap F. G., Kleinjans J. C. S.
Toxicol In Vitro. 2017 Oct;44:322-329. doi: 10.1016/j.tiv.2017.07.024. Epub 2017 Aug 1. PMID: 28778767 [PubMed - indexed for MEDLINE] Free Article
A model-based assay design to reproduce in vivo patterns of acute drug-induced toxicity.
Kuepfer L., Clayton O., Thiel C., Cordes H., Nudischer R., Blank L. M., Baier V., Heymans S., Caiment F., Roth A., Fluri D. A., Kelm J. M., Castell J., Selevsek N., Schlapbach R., Keun H., Hynes J., Sarkans U., Gmuender H., Herwig R., Niederer S., Schuchhardt J., Segall M., Kleinjans J.
Arch Toxicol. 2018 Jan;92(1):553-555. doi: 10.1007/s00204-017-2041-7. Epub 2017 Aug 29. No abstract available. PMID: 28852801 [PubMed - in process] Free PMC Article
Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes.
Wolters J. E. J, van Breda S. G. J., Grossmann J., Fortes C., Caiment F., Kleinjans J. C. S.
Toxicol Lett. 2018 Jun 1;289:1-13. doi: 10.1016/j.toxlet.2018.02.026. Epub 2018 Mar 6. PMID: 29501571 [PubMed - indexed for MEDLINE]
SOX10 Single Transcription Factor-Based Fast and Efficient Generation of Oligodendrocytes from Human Pluripotent Stem Cells.
García-León J. A., Kumar M., Boon R., Chau D., One J., Wolfs E., Eggermont K., Berckmans P., Gunhanlar N., de Vrij F., Lendemeijer B., Pavie B., Corthout N., Kushner S. A., Dávila J. C., Lambrichts I., Hu W. S., Verfaillie C. M.
Stem Cell Reports. 2018 Feb 13;10(2):655-672. doi: 10.1016/j.stemcr.2017.12.014. Epub 2018 Jan 11. PMID: 29337119 [PubMed - in process] Free PMC Article
Efficient Recombinase-Mediated Cassette Exchange in hPSCs to Study the Hepatocyte Lineage Reveals AAVS1 Locus-Mediated Transgene Inhibition.
Ordovás L., Boon R., Pistoni M., Chen Y., Wolfs E., Guo W., Sambathkumar R., Bobis-Wozowicz S., Helsen N., Vanhove J., Berckmans P., Cai Q, Vanuytsel K., Eggermont K., Vanslembrouck V., Schmidt B. Z., Raitano S., Van Den Bosch L., Nahmias Y., Cathomen T., Struys T., Verfaillie C. M..
Ordovás L, Boon R, Pistoni M, Chen Y, Wolfs E, Guo W, Sambathkumar R, Bobis-Wozowicz S, Helsen N, Vanhove J, Berckmans P, Cai Q, Vanuytsel K, Eggermont K, Vanslembrouck V, Schmidt BZ, Raitano S, Van Den Bosch L, Nahmias Y, Cathomen T, Struys T, Verfaillie
Strategies for In Vivo Genome Editing in Nondividing Cells.
Nami F., Basiri M., Satarian L., Curtiss C., Baharvand H., Verfaillie C.
Trends Biotechnol. 2018 Apr 21. pii: S0167-7799(18)30088-X. doi: 10.1016/j.tibtech.2018.03.004. [Epub ahead of print] Review. PMID: 29685818 [PubMed - as supplied by publisher]
Generation of hepatocyte- and endocrine pancreatic-like cells from human induced endodermal progenitor cells.
Sambathkumar R., Akkerman R., Dastidar S., Roelandt P., Kumar M., Bajaj M., Mestre Rosa A. R., Helsen N., Vanslembrouck V., Kalo E., Khurana S., Laureys J., Gysemans C., Faas M. M., de Vos P., Verfaillie C. M.
PLoS One. 2018 May 11;13(5):e0197046. doi: 10.1371/journal.pone.0197046. eCollection 2018. PMID: 29750821 [PubMed - in process] Free PMC Article
Prediction of liver toxicity and mode of action using metabolomics in vitro in HepG2 cells.
Ramirez T., Strigun A., Verlohner A., Huener H. A., Peter E., Herold M., Bordag N., Mellert W., Walk T., Spitzer M., Jiang X., Sperber S., Hofmann T., Hartung T., Kamp H., van Ravenzwaay B.
Arch Toxicol. 2018 Feb;92(2):893-906. doi: 10.1007/s00204-017-2079-6. Epub 2017 Sep 30. PMID: 28965233 [PubMed - in process] Free PMC Article
Framework for the quality assurance of 'omics technologies considering GLP requirements.
Kauffmann H. M., Kamp H., Fuchs R., Chorley B. N., Deferme L., Ebbels T., Hackermüller J., Perdichizzi S., Poole A., Sauer U. G., Tollefsen K. E., Tralau T., Yauk C., van Ravenzwaay B.
Regul Toxicol Pharmacol. 2017 Dec;91 Suppl 1:S27-S35. doi: 10.1016/j.yrtph.2017.10.007. Epub 2017 Oct 5. PMID: 28987912 [PubMed - in process] Free Article
Legacy data sharing to improve drug safety assessment: the eTOX project.
Sanz F., Pognan F., Steger-Hartmann T., Díaz C.; eTOX, Cases M., Pastor M., Marc P., Wichard J., Briggs K., Watson D. K., Kleinöder T., Yang C., Amberg A., Beaumont M., Brookes A. J., Brunak S., Cronin M. T. D., Ecker G. F., Escher S., Greene N., Guzmán A., Hersey A., Jacques P., Lammens L., Mestres J., Muster W., Northeved H., Pinches M., Saiz J., Sajot N., Valencia A., van der Lei J., Vermeulen N. P. E., Vock E., Wolber G., Zamora I.
Nat Rev Drug Discov. 2017 Dec;16(12):811-812. doi: 10.1038/nrd.2017.177. Epub 2017 Oct 13. PMID: 29026211 [PubMed - indexed for MEDLINE]
New microRNA Biomarkers for Drug-Induced Steatosis and Their Potential to Predict the Contribution of Drugs to Non-alcoholic Fatty Liver Disease.
López-Riera M., Conde I., Tolosa L., Zaragoza Á., Castell J. V., Gómez-Lechón M. J., Jover R.
López-Riera M, Conde I, Tolosa L, Zaragoza Á, Castell JV, Gómez-Lechón MJ, Jover R. Front Pharmacol. 2017 Jan 25;8:3. doi: 10.3389/fphar.2017.00003. eCollection 2017. PMID: 28179883 [PubMed] Free PMC Article
Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury.
Tolosa L., Jiménez N., Pérez G., Castell J. V., Gómez-Lechón M. J., Donato M. T.
Arch Toxicol. 2018 Jan;92(1):383-399. doi: 10.1007/s00204-017-2036-4. Epub 2017 Jul 31. PMID: 28762043
Predicting drug-induced cholestasis: preclinical models.
Petrov P. D., Fernández-Murga M. L., López-Riera M., Goméz-Lechón M. J., Castell J. V., Jover R.
Expert Opin Drug Metab Toxicol. 2018 Jun 11. doi: 10.1080/17425255.2018.1487399. [Epub ahead of print] PMID: 29888962 [PubMed - as supplied by publisher]
The application of new HARD-descriptor available from the CORAL software to building up NOAEL models.
Toropova A. P., Toropov A. A., Marzo M., Escher S. E., Dorne J. L., Georgiadis N., Benfenati E.
Food Chem Toxicol. 2018 Feb;112:544-550. doi: 10.1016/j.fct.2017.03.060. Epub 2017 Mar 30. PMID: 28366846
Exposure to PFOA and PFOS and fetal growth: a critical merging of toxicological and epidemiological data.
Negri E., Metruccio F., Guercio V., Tosti L., Benfenati E., Bonzi R., La Vecchia C., Moretto A.
Negri E, Metruccio F, Guercio V, Tosti L, Benfenati E, Bonzi R, La Vecchia C, Moretto A. Crit Rev Toxicol. 2017 Jul;47(6):482-508. doi: 10.1080/10408444.2016.1271972. Epub 2017 Feb 15. Review. PMID: 28617200 [PubMed - indexed for MEDLINE]
SAR for gastro-intestinal absorption and blood-brain barrier permeation of pesticides.
Toropov A. A., Toropova A. P., Benfenati E., Dorne J. L.
Chem Biol Interact. 2018 Jun 25;290:1-5. doi: 10.1016/j.cbi.2018.04.030. Epub 2018 May 16. PMID: 29753609
QSARpy: A new flexible algorithm to generate QSAR models based on dissimilarities. The log Kow case study.
Ferrari T., Lombardo A., Benfenati E.
Sci Total Environ. 2018 Oct 1;637-638:1158-1165. doi: 10.1016/j.scitotenv.2018.05.072. Epub 2018 May 14. PMID: 29801209
Adverse outcome pathways: a concise introduction for toxicologists.
Vinken M., Knapen D., Vergauwen L., Hengstler J. G., Angrish M., Whelan M.
Arch Toxicol. 2017 Nov;91(11):3697-3707. doi: 10.1007/s00204-017-2020-z. Epub 2017 Jun 28. PMID: 28660287
A frequent misinterpretation in current research on liver fibrosis: the vessel in the center of CCl<sub>4</sub>-induced pseudolobules is a portal vein.
Hammad S., Braeuning A., Meyer C., Feza M., Hengstler J. G., Dooley S.
Arch Toxicol. 2017 Nov;91(11):3689-3692. doi: 10.1007/s00204-017-2040-8. Epub 2017 Aug 19. PMID: 28825120
Comprehensive Landscape of Nrf2 and p53 Pathway Activation Dynamics by Oxidative Stress and DNA Damage.
Hiemstra S., Niemeijer M., Koedoot E., Wink S., Klip J. E., Vlasveld M., de Zeeuw E., van Os B., White A., Water B. V.
Chem Res Toxicol. 2017 Apr 17;30(4):923-933. doi: 10.1021/acs.chemrestox.6b00322. Epub 2016 Dec 16. PMID: 27982581 [PubMed - indexed for MEDLINE]
Highlight report: 'Big data in the 3R's: outlook and recommendations', a roundtable summary.
Mahony C., Currie R., Daston G., Kleinstreuer N., van de Water B.
Arch Toxicol. 2018 Feb;92(2):1015-1020. doi: 10.1007/s00204-017-2145-0. Epub 2018 Jan 16. No abstract available. PMID: 29340744
Dynamic imaging of adaptive stress response pathway activation for prediction of drug induced liver injury.
Wink S., Hiemstra S. W., Huppelschoten S., Klip J. E., van de Water B.
Arch Toxicol. 2018 May;92(5):1797-1814. doi: 10.1007/s00204-018-2178-z. Epub 2018 Mar 3. PMID: 29502165
Ab initio chemical safety assessment: A workflow based on exposure considerations and non-animal methods.
Berggren E., White A., Ouedraogo G., Paini A., Richarz A. N., Bois F. Y., Exner T., Leite S., Grunsven L. A. V., Worth A., Mahony C.
Comput Toxicol. 2017 Nov;4:31-44. doi: 10.1016/j.comtox.2017.10.001. PMID: 29214231 [PubMed] Free PMC Article
Towards optimisation of induced pluripotent cell culture: Extracellular acidification results in growth arrest of iPSC prior to nutrient exhaustion.
Wilmes A., Rauch C., Carta G., Kern G., Meier F., Posch W., Wilflingseder D., Armstrong L., Lako M., Beilmann M., Gstraunthaler G., Jennings P.
Toxicol In Vitro. 2017 Dec;45(Pt 3):445-454. doi: 10.1016/j.tiv.2017.07.023. Epub 2017 Aug 15. PMID: 28821352 [PubMed - in process]
A snapshot on the progress of in vitro toxicology for safety assessment.
Jennings P., Corvi R., Culot M..
Toxicol In Vitro. 2017 Dec;45(Pt 3):269-271. doi: 10.1016/j.tiv.2017.10.024. No abstract available. PMID: 29195642 [PubMed - in process]
T. Luechtefeld, C. Rowlands and T. Hartung
Toxicol. Res., 2018, DOI: 10.1039/C8TX00051D
Alice Krebs, Johanna Nyffeler, Jörg Rahnenführer and Marcel Leist
Received: March 23, 2018; doi:10.14573/altex.1803231; ALTEX 35(2), 2018
Johannes Delp, Simon Gutbier, Stefanie Klima, Lisa Hoelting, Kevin Pinto-Gil, Jui-Hua Hsieh, Michael Aichem, Karsten Klein, Falk Schreiber, Raymond R. Tice, Manuel Pastor, Mamta Behl and Marcel Leist
January 21, 2018; doi:10.14573/altex.1712182; ALTEX 35(2), 2018
Lena Smirnova, Nicole Kleinstreuer, Raffaella Corvi, Andre Levchenko, Suzanne C. Fitzpatrick and Thomas Hartung
April 5, 2018; doi:10.14573/altex.180
Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity
Bal-Price A., Hogberg H.T., Crofton K.M., Daneshian M., FitzGerald R.E., Fritsche E., Heinonen T., Hougaard Bennekou S., Klima S., Piersma A.H., Sachana M., Shafer T.J., Terron A., Monnet-Tschudi F., Viviani B., Waldmann T., Westerink R.H.S., Wilks M.F., Witters H., Zurich M.G., Leist M.
ALTEX. 2018 Feb 23. doi: 10.14573/altex.1712081. [Epub ahead of print]
Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes
Fritsche E., Grandjean P., Crofton K.M., Aschner M., Goldberg A., Heinonen T., Hessel E.V.S., Hogberg H.T., Bennekou S.H., Lein P.J., Leist M., Mundy W.R., Paparella M., Piersma A.H., Sachana M., Schmuck G., Solecki R., Terron A., Monnet-Tschudi F., Wilks M.F., Witters H., Zurich M.G., Bal-Price A.
Toxicol Appl Pharmacol. 2018 Feb 12. pii: S0041-008X(18)30043-7. doi: 10.1016/j.taap.2018.02.004. [Epub ahead of print]
A high-throughput approach to identify specific neurotoxicants/ developmental toxicants in human neuronal cell function assays
Delp J., Gutbier S., Klima S., Hoelting L., Pinto-Gil K., Hsieh J.H., Aichem M., Klein K., Schreiber F., Tice R.R., Pastor M., Behl M., Leist M.
ALTEX. 2018 Jan 21. doi: 10.14573/altex.1712182. [Epub ahead of print]
Stage-specific metabolic features of differentiating neurons: Implications for toxicant sensitivity
Delp J., Gutbier S., Cerff M., Zasada C., Niedenführ S., Zhao L., Smirnova L., Hartung T., Borlinghaus H., Schreiber F., Bergemann J., Gätgens J., Beyss M., Azzouzi S., Waldmann T., Kempa S., Nöh K., Leist M.
Toxicol Appl Pharmacol. 2017 Dec 24. pii: S0041-008X(17)30494-5. doi: 10.1016/j.taap.2017.12.013. [Epub ahead of print]
An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition
Terron A., Bal-Price A., Paini A., Monnet-Tschudi F., Bennekou S.H.; EFSA WG EPI1 Members, Leist M., Schildknecht S.
Arch Toxicol. 2018 Jan;92(1):41-82. doi: 10.1007/s00204-017-2133-4. Epub 2017 Dec 5. Review.
A structure-activity relationship linking non-planar PCBs to functional deficits of neural crest cells: new roles for connexins
Nyffeler J., Chovancova P., Dolde X., Holzer A.K., Purvanov V., Kindinger I., Kerins A., Higton D., Silvester S., van Vugt-Lussenburg B.M.A., Glaab E., van der Burg B., Maclennan R., Legler D.F., Leist M.
Arch Toxicol. 2017 Nov 21. doi: 10.1007/s00204-017-2125-4. [Epub ahead of print]
New animal-free concepts and test methods for developmental toxicity and peripheral neurotoxicity
Leist M.
Altern Lab Anim. 2017 Nov;45(5):253-260.
Adverse outcome pathways: opportunities, limitations and open questions
Leist M., Ghallab A., Graepel R., Marchan R., Hassan R., Bennekou S.H., Limonciel A., Vinken M., Schildknecht S., Waldmann T., Danen E., van Ravenzwaay B., Kamp H., Gardner I., Godoy P., Bois F.Y., Braeuning A., Reif R., Oesch F., Drasdo D., Höhme S., Schwarz M., Hartung T., Braunbeck T., Beltman J., Vrieling H., Sanz F., Forsby A., Gadaleta D., Fisher C., Kelm J., Fluri D., Ecker G., Zdrazil B., Terron A., Jennings P., van der Burg B., Dooley S., Meijer A.H., Willighagen E., Martens M., Evelo C., Mombelli E., Taboureau O., Mantovani A., Hardy B., Koch B., Escher S., van Thriel C., Cadenas C., Kroese D., van de Water B., Hengstler J.G.
Arch Toxicol. 2017 Nov;91(11):3477-3505. doi: 10.1007/s00204-017-2045-3. Epub 2017 Oct 19.
Combination of multiple neural crest migration assays to identify environmental toxicants from a proof-of-concept chemical library
Nyffeler J., Dolde X., Krebs A., Pinto-Gil K., Pastor M., Behl M., Waldmann T., Leist M.
Arch Toxicol. 2017 Nov;91(11):3613-3632. doi: 10.1007/s00204-017-1977-y. Epub 2017 May 5.
Tipping Points and Endogenous Determinants of Nigrostriatal Degeneration by MPTP
Schildknecht S., Di Monte D.A., Pape R., Tieu K., Leist M.
Trends Pharmacol Sci. 2017 Jun;38(6):541-555. doi: 10.1016/j.tips.2017.03.010. Epub 2017 Apr 23. Review.
OECD/EFSA workshop on developmental neurotoxicity (DNT): The use of non-animal test methods for regulatory purposes
Fritsche E., Crofton K.M., Hernandez A.F., Hougaard Bennekou S., Leist M., Bal-Price A., Reaves E., Wilks M.F., Terron A., Solecki R., Sachana M., Gourmelon A.
ALTEX. 2017;34(2):311-315. doi: 10.14573/altex.1701171. No abstract available.
Impairment of human neural crest cell migration by prolonged exposure to interferon-beta
Pallocca G., Nyffeler J., Dolde X., Grinberg M., Gstraunthaler G., Waldmann T., Rahnenführer J., Sachinidis A., Leist M.
Arch Toxicol. 2017 Oct;91(10):3385-3402. doi: 10.1007/s00204-017-1966-1. Epub 2017 Apr 1.
Stem Cell Transcriptome Responses and Corresponding Biomarkers That Indicate the Transition from Adaptive Responses to Cytotoxicity
Waldmann T., Grinberg M., König A., Rempel E., Schildknecht S., Henry M., Holzer A.K., Dreser N., Shinde V., Sachinidis A., Rahnenführer J., Hengstler J.G., Leist M.
Chem Res Toxicol. 2017 Apr 17;30(4):905-922. doi: 10.1021/acs.chemrestox.6b00259. Epub 2016 Dec 21.
Hybrid optimal descriptors as a tool to predict skin sensitization in accordance to OECD principles
A. P. Toropova, A. A. Toropov
Toxicology Letters 275 (2017) 57–66
The index of ideality of correlation: A criterion of predictability of QSAR models for skin permeability?
A. P. Toropova, A. A. Toropov
Science of the Total Environment 586 (2017) 466–472
The application of new HARD-descriptor available from the CORAL software to building up NOAEL models
A. P. Toropova, A. A. Toropov, M. Marzo, S. E. Escher, J. L. Dorne, N. Georgiadis, E. Benfenati
Food and Chemical Toxicology xxx (2017) 1-7
The index of ideality of correlation: A criterion of predictive potential of QSPR/QSAR models?
A. A. Toropov, A. P. Toropova
Mutat Res Gen Tox En 819 (2017) 31–37
CORAL: Binary classifications (active/inactive) for drug-induced liver injury
A. P. Toropova, A. A. Toropov
Toxicology Letters 268 (2017) 51–57
Human environmental disease network: A computational model to assess toxicology of contaminants
O. Taboureau and K. Audouze
Altex, published October 21, 2016
In Silico Systems Pharmacology to Assess Drug's Therapeutic and Toxic Effects
A. Aguayo-Orozco; K. Audouze; S. Brunak; O. Taboureau
Current Pharmaceutical Design, Volume 22, Number 46, December 2016, pp. 6895-6902(8) - DOI: 10.2174/1381612822666160907093215
The ascending pathophysiology of cholestatic liver disease
P.L. Jansen, A Ghallab, N. Vartak, R. Reif, F.G. Schaap, J. Hampe, J.G. Hengstler
Hepatology. 2017 Feb;65(2):722-738
In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities
B. Z. Schmidt, M. Lehmann, S. Gutbier, E. Nembo, S. Noel, L. Smirnova, A. Forsby, J. Hescheler, H. X. Avci, T. Hartung, M. Leist, J. Kobolák, A. Dinnyés
January 2017 - Arch Toxicol - DOI: 10.1007/s00204-016-1805-9
Improved building up a model of toxicity towards Pimephales promelas by the Monte Carlo method
A. P. Toropovaa, A. A. Toropova, M. Raskovab, I. Raska
November 2016 - Environmental Toxicology and Pharmacology 48 (2016) 278–285
A Multi-Compartment Liver Model for the Prediction of Toxicokinetics
C. Fisher, O. Hatley, I. Gardner, M. Jamei
September 2016 - Toxicology Letters 258S (2016) S62–S324
Unraveling cellular pathways contributing to drug-induced liver injury by dynamical modeling
I.A. Kuijper, H. Yang, B. Van De Water, J.B. Beltman
Expert Opin Drug Metab Toxicol. 2016 Sep 23:1-13 - DOI:10.1080/17425255.2017.1234607
A. Chandrasekaran, H. X. Avci1, M. Leist, J. Kobolak and A. Dinnyes
September 2016 - Front. Cell. Neurosci. 10:215. doi:10.3389/fncel.2016.00215
Good Cell Culture Practice for Stem Cells and Stem-Cell-Derived Models
D. Pamies, A. Bal-Price, A. Simeonov, D. Tagle, D. Allen, D. Gerhold, D. Yin, F. Pistollato, T. Inutsuka, K. Sullivan, G. Stacey, H. Salem, M. Leist, M. Daneshian, M.C. Vemuri, R. McFarland, S. Coecke, S. C. Fitzpatrick, U. Lakshmipathy, A. Mack, W. Bo Wang, D. Yamazaki, Y. Sekino, Y. Kanda, L. Smirnova and T. Hartung
August 2016 - ALTEX 34(1), 2017 - 10.14573/altex.1607121
Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use
M. Aschner, S.Ceccatelli, M. Daneshian, E. Fritsche, N. Hasiwa, T. Hartung, H. T. Hogberg, M. Leist, A. Li, W.R. Mundy, S. Padilla, A. H. Piersma, A. Bal-Price, A. Seiler, R. Westerink , B. Zimmer, P. Lein
July 2016 - DOI: 10.14573/altex.1604201
V. Shinde, L. Hoelting, S. P. Srinivasan, J. Meisig, K. Meganathan, S. Jagtap, M. Grinberg, J. Liebing, N. Bluethgen, J. Rahnenführer, E. Rempel, R. Stoeber, S. Schildknecht, S. Förster, P. Godoy, C. van Thriel, J. A. Gaspar, J. Hescheler, T. Waldmann, J. Hengstler, M. Leist, A. Sachinidis
May 2016 - Arch Toxicol - DOI 10.1007/s00204-016-1741-8
M. Daneshian, H. Kamp, J. Hengstler, M. Leist, B. van de Water
March 2016 - Arch Toxicol - DOI 10.1007/s00204-016-1698-7
N. Ball, M. T. D. Cronin, J. Shen, K. Blackburn, E. D. Booth, M. Bouhifd, E. Donley, L. Egnash, C. Hastings, D. R. Juberg, A. Kleensang, N. Kleinstreuer, E. D. Kroese, A. C. Lee, T. Luechtefeld, A. Maertens, S. Marty, J. M. Naciff, J. Palmer, D. Pamies, M. Penman, A.N. Richarz, D. P. Russo, S. B. Stuard, G. Patlewicz, B. van Ravenzwaay, S. Wu, H. Zhu and T. Hartung
ALTEX 33(2), 2016
