Introducing WikiPathways as a Data-Source to Support Adverse Outcome Pathways for Regulatory Risk Assessment of Chemicals and Nanomaterials
Marvin Martens, Tim Verbruggen, Penny Nymark, Roland Grafström, Lyle D. Burgoon, Hristo Aladjov, Fernando Torres Andón, Chris T. Evelo and Egon L. Willighagen
Front. Genet., 21 December 2018, doi: 10.3389/fgene.2018.00661
VIVD: Virtual in vitro distribution model for the mechanistic prediction of intracellular concentrations of chemicals in in vitro toxicity assays
Fisher, C., Siméon, S., Jamei, M., Gardner, I., Bois, Y.F.
Toxicology in Vitro, December 2018,DOI:10.1016/j.tiv.2018.12.017
Persistence of Epigenomic Effects After Recovery From Repeated Treatment With Two Nephrocarcinogens.
Limonciel A, van Breda SG, Jiang X, Tredwell GD, Wilmes A, Aschauer L, Siskos AP, Sachinidis A, Keun HC, Kopp-Schneider A, de Kok TM, Kleinjans JCS, Jennings P1.
Front Genet. 2018 Dec 3;9:558. doi: 10.3389/fgene.2018.00558. eCollection 2018.
A new semi-automated workflow for chemical data retrieval and quality checking for modeling applications
Domenico Gadaleta, Anna Lombardo, Cosimo Toma, Emilio Benfenati
Journal of Cheminformatics 201810:60, doi.org/10.1186/s13321-018-0315-6
Major changes of cell function and toxicant sensitivity in cultured cells undergoing mild, quasi-natural genetic drift
Gutbier, S., May, P., Berthelot, S. et al.
Arch Toxicol. 2018 Oct 8, DOI: 10.1007/s00204-018-2326-5
Development of an Infrastructure for the Prediction of Biological Endpoints in Industrial Environments. Lessons Learned at the eTOX Project
Pastor M, Quintana J and Sanz F
Front. Pharmacol., 11 October 2018, DOI: 10.3389/fphar.2018.01147
Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes
Xiaolong Gu, · Wiebke Albrecht, · Karolina Edlund · Franziska Kappenberg, · Jörg Rahnenführer, · Marcel Leist, · Wolfgang Moritz, · Patricio Godoy, · Cristina Cadenas, · Rosemarie Marchan, · Tim Brecklinghaus · Laia Tolosa Pardo6 · José V. Castell6 · Iain Gardner7 · Bo Han2 · Jan G. Hengstler1 · Regina Stoeber1
Arch Toxicol. 2018 Oct 13, DOI: 10.1007/s00204-018-2302-0
QSAR Modeling of ToxCast Assays Relevant to the Molecular Initiating Events of AOPs Leading to Hepatic Steatosis
Gadaleta D., Manganelli S., Roncaglioni A., Toma C., Benfenati E., Mombelli E.
J. Chem. Inf. Model. 58, 8, 1501-1517; DOI: 10.1021/acs.jcim.8b00297
Alice Limonciel, Gamze Ates, Giada Carta, Anja Wilmes, Manfred Watzele, Peter J. Shepard, Harper C. VanSteenhouse, Bruce Seligmann, Joanne M. Yeakley, Bob van de Water, Mathieu Vinken Email, Paul Jennings
Limonciel, A., Ates, G., Carta, G. et al. Arch Toxicol (2018). https://doi.org/10.1007/s00204-018-2256-2
Generation of Hepatic Stellate Cells from Human Pluripotent Stem Cells Enables In Vitro Modeling of Liver Fibrosis
Mar Coll, Luis Perea, Ruben Boon, Sofia B. Leite, Julia Vallverdú, Inge Mannaerts, Ayla Smout, Adil El Taghdouini, Delia Blaya, Daniel Rodrigo-Torres, Isabel Graupera, Beatriz Aguilar-Bravo, Christophe Chesne, Mustapha Najimi, Etienne Sokal, Juan José Lozano, Leo A. van Grunsven, Catherine M. Verfaillie, Pau Sancho-Bru
Cell Stem Cell (2018), https://doi.org/10.1016/j.stem.2018.05.027
Comparing the performance of meta-classifiers-a case study on selected imbalanced data sets relevant for prediction of liver toxicity.
Jain S., Kotsampasakou E., Ecker G. F.
J Comput Aided Mol Des. 2018 May;32(5):583-590. doi: 10.1007/s10822-018-0116-z. Epub 2018 Apr 6. PMID: 29626291 [PubMed - in process] Free PMC Article
Insights into the Structure, Function, and Ligand Discovery of the Large Neutral Amino Acid Transporter 1, LAT1.
Singh N., Ecker G. F.
Int J Mol Sci. 2018 Apr 24;19(5). pii: E1278. doi: 10.3390/ijms19051278. Review. PMID: 29695141 [PubMed - in process] Free PMC Article
Predicting drug resistance related to ABC transporters using unsupervised Consensus Self-Organizing Maps.
Estrada-Tejedor R., Ecker G. F..
Sci Rep. 2018 May 1;8(1):6803. doi: 10.1038/s41598-018-25235-9. PMID: 29717183 [PubMed - in process] Free Article
Human Environmental Disease Network: A computational model to assess toxicology of contaminants.
Taboureau O, Audouze K.
ALTEX. 2017;34(2):289-300. doi: 10.14573/altex.1607201. Epub 2016 Oct 21. PMID: 27768803 [PubMed - indexed for MEDLINE]
A systems biology approach to predictive developmental neurotoxicity of a larvicide used in the prevention of Zika virus transmission.
Audouze K., Taboureau O., Grandjean P..
Toxicol Appl Pharmacol. 2018 Feb 21. pii: S0041-008X(18)30060-7. doi: 10.1016/j.taap.2018.02.014. [Epub ahead of print] PMID: 29476864 [PubMed - as supplied by publisher]
DTNI: a novel toxicogenomics data analysis tool for identifying the molecular mechanisms underlying the adverse effects of toxic compounds.
Hendrickx D. M., Souza T., Jennen D. G. J., Kleinjans J. C. S.
Arch Toxicol. 2017 Jun;91(6):2343-2352. doi: 10.1007/s00204-016-1922-5. Epub 2016 Dec 28. PMID: 28032149 [PubMed - indexed for MEDLINE] Free PMC Article
Validation of gene expression profiles from cholestatic hepatotoxicants in vitro against human in vivo cholestasis.
Van den Hof W. F. P. M., Coonen M. L. J., van Herwijnen M., Brauers K., Jennen D., Olde Damink S. W. M., Schaap F. G., Kleinjans J. C. S.
Toxicol In Vitro. 2017 Oct;44:322-329. doi: 10.1016/j.tiv.2017.07.024. Epub 2017 Aug 1. PMID: 28778767 [PubMed - indexed for MEDLINE] Free Article
A model-based assay design to reproduce in vivo patterns of acute drug-induced toxicity.
Kuepfer L., Clayton O., Thiel C., Cordes H., Nudischer R., Blank L. M., Baier V., Heymans S., Caiment F., Roth A., Fluri D. A., Kelm J. M., Castell J., Selevsek N., Schlapbach R., Keun H., Hynes J., Sarkans U., Gmuender H., Herwig R., Niederer S., Schuchhardt J., Segall M., Kleinjans J.
Arch Toxicol. 2018 Jan;92(1):553-555. doi: 10.1007/s00204-017-2041-7. Epub 2017 Aug 29. No abstract available. PMID: 28852801 [PubMed - in process] Free PMC Article
Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes.
Wolters J. E. J, van Breda S. G. J., Grossmann J., Fortes C., Caiment F., Kleinjans J. C. S.
Toxicol Lett. 2018 Jun 1;289:1-13. doi: 10.1016/j.toxlet.2018.02.026. Epub 2018 Mar 6. PMID: 29501571 [PubMed - indexed for MEDLINE]
SOX10 Single Transcription Factor-Based Fast and Efficient Generation of Oligodendrocytes from Human Pluripotent Stem Cells.
García-León J. A., Kumar M., Boon R., Chau D., One J., Wolfs E., Eggermont K., Berckmans P., Gunhanlar N., de Vrij F., Lendemeijer B., Pavie B., Corthout N., Kushner S. A., Dávila J. C., Lambrichts I., Hu W. S., Verfaillie C. M.
Stem Cell Reports. 2018 Feb 13;10(2):655-672. doi: 10.1016/j.stemcr.2017.12.014. Epub 2018 Jan 11. PMID: 29337119 [PubMed - in process] Free PMC Article
Efficient Recombinase-Mediated Cassette Exchange in hPSCs to Study the Hepatocyte Lineage Reveals AAVS1 Locus-Mediated Transgene Inhibition.
Ordovás L., Boon R., Pistoni M., Chen Y., Wolfs E., Guo W., Sambathkumar R., Bobis-Wozowicz S., Helsen N., Vanhove J., Berckmans P., Cai Q, Vanuytsel K., Eggermont K., Vanslembrouck V., Schmidt B. Z., Raitano S., Van Den Bosch L., Nahmias Y., Cathomen T., Struys T., Verfaillie C. M..
Ordovás L, Boon R, Pistoni M, Chen Y, Wolfs E, Guo W, Sambathkumar R, Bobis-Wozowicz S, Helsen N, Vanhove J, Berckmans P, Cai Q, Vanuytsel K, Eggermont K, Vanslembrouck V, Schmidt BZ, Raitano S, Van Den Bosch L, Nahmias Y, Cathomen T, Struys T, Verfaillie
Strategies for In Vivo Genome Editing in Nondividing Cells.
Nami F., Basiri M., Satarian L., Curtiss C., Baharvand H., Verfaillie C.
Trends Biotechnol. 2018 Apr 21. pii: S0167-7799(18)30088-X. doi: 10.1016/j.tibtech.2018.03.004. [Epub ahead of print] Review. PMID: 29685818 [PubMed - as supplied by publisher]
Generation of hepatocyte- and endocrine pancreatic-like cells from human induced endodermal progenitor cells.
Sambathkumar R., Akkerman R., Dastidar S., Roelandt P., Kumar M., Bajaj M., Mestre Rosa A. R., Helsen N., Vanslembrouck V., Kalo E., Khurana S., Laureys J., Gysemans C., Faas M. M., de Vos P., Verfaillie C. M.
PLoS One. 2018 May 11;13(5):e0197046. doi: 10.1371/journal.pone.0197046. eCollection 2018. PMID: 29750821 [PubMed - in process] Free PMC Article
Prediction of liver toxicity and mode of action using metabolomics in vitro in HepG2 cells.
Ramirez T., Strigun A., Verlohner A., Huener H. A., Peter E., Herold M., Bordag N., Mellert W., Walk T., Spitzer M., Jiang X., Sperber S., Hofmann T., Hartung T., Kamp H., van Ravenzwaay B.
Arch Toxicol. 2018 Feb;92(2):893-906. doi: 10.1007/s00204-017-2079-6. Epub 2017 Sep 30. PMID: 28965233 [PubMed - in process] Free PMC Article
Framework for the quality assurance of 'omics technologies considering GLP requirements.
Kauffmann H. M., Kamp H., Fuchs R., Chorley B. N., Deferme L., Ebbels T., Hackermüller J., Perdichizzi S., Poole A., Sauer U. G., Tollefsen K. E., Tralau T., Yauk C., van Ravenzwaay B.
Regul Toxicol Pharmacol. 2017 Dec;91 Suppl 1:S27-S35. doi: 10.1016/j.yrtph.2017.10.007. Epub 2017 Oct 5. PMID: 28987912 [PubMed - in process] Free Article
Legacy data sharing to improve drug safety assessment: the eTOX project.
Sanz F., Pognan F., Steger-Hartmann T., Díaz C.; eTOX, Cases M., Pastor M., Marc P., Wichard J., Briggs K., Watson D. K., Kleinöder T., Yang C., Amberg A., Beaumont M., Brookes A. J., Brunak S., Cronin M. T. D., Ecker G. F., Escher S., Greene N., Guzmán A., Hersey A., Jacques P., Lammens L., Mestres J., Muster W., Northeved H., Pinches M., Saiz J., Sajot N., Valencia A., van der Lei J., Vermeulen N. P. E., Vock E., Wolber G., Zamora I.
Nat Rev Drug Discov. 2017 Dec;16(12):811-812. doi: 10.1038/nrd.2017.177. Epub 2017 Oct 13. PMID: 29026211 [PubMed - indexed for MEDLINE]
New microRNA Biomarkers for Drug-Induced Steatosis and Their Potential to Predict the Contribution of Drugs to Non-alcoholic Fatty Liver Disease.
López-Riera M., Conde I., Tolosa L., Zaragoza Á., Castell J. V., Gómez-Lechón M. J., Jover R.
López-Riera M, Conde I, Tolosa L, Zaragoza Á, Castell JV, Gómez-Lechón MJ, Jover R. Front Pharmacol. 2017 Jan 25;8:3. doi: 10.3389/fphar.2017.00003. eCollection 2017. PMID: 28179883 [PubMed] Free PMC Article
Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury.
Tolosa L., Jiménez N., Pérez G., Castell J. V., Gómez-Lechón M. J., Donato M. T.
Arch Toxicol. 2018 Jan;92(1):383-399. doi: 10.1007/s00204-017-2036-4. Epub 2017 Jul 31. PMID: 28762043
Predicting drug-induced cholestasis: preclinical models.
Petrov P. D., Fernández-Murga M. L., López-Riera M., Goméz-Lechón M. J., Castell J. V., Jover R.
Expert Opin Drug Metab Toxicol. 2018 Jun 11. doi: 10.1080/17425255.2018.1487399. [Epub ahead of print] PMID: 29888962 [PubMed - as supplied by publisher]
The application of new HARD-descriptor available from the CORAL software to building up NOAEL models.
Toropova A. P., Toropov A. A., Marzo M., Escher S. E., Dorne J. L., Georgiadis N., Benfenati E.
Food Chem Toxicol. 2018 Feb;112:544-550. doi: 10.1016/j.fct.2017.03.060. Epub 2017 Mar 30. PMID: 28366846
Exposure to PFOA and PFOS and fetal growth: a critical merging of toxicological and epidemiological data.
Negri E., Metruccio F., Guercio V., Tosti L., Benfenati E., Bonzi R., La Vecchia C., Moretto A.
Negri E, Metruccio F, Guercio V, Tosti L, Benfenati E, Bonzi R, La Vecchia C, Moretto A. Crit Rev Toxicol. 2017 Jul;47(6):482-508. doi: 10.1080/10408444.2016.1271972. Epub 2017 Feb 15. Review. PMID: 28617200 [PubMed - indexed for MEDLINE]
SAR for gastro-intestinal absorption and blood-brain barrier permeation of pesticides.
Toropov A. A., Toropova A. P., Benfenati E., Dorne J. L.
Chem Biol Interact. 2018 Jun 25;290:1-5. doi: 10.1016/j.cbi.2018.04.030. Epub 2018 May 16. PMID: 29753609
QSARpy: A new flexible algorithm to generate QSAR models based on dissimilarities. The log Kow case study.
Ferrari T., Lombardo A., Benfenati E.
Sci Total Environ. 2018 Oct 1;637-638:1158-1165. doi: 10.1016/j.scitotenv.2018.05.072. Epub 2018 May 14. PMID: 29801209
Adverse outcome pathways: a concise introduction for toxicologists.
Vinken M., Knapen D., Vergauwen L., Hengstler J. G., Angrish M., Whelan M.
Arch Toxicol. 2017 Nov;91(11):3697-3707. doi: 10.1007/s00204-017-2020-z. Epub 2017 Jun 28. PMID: 28660287
A frequent misinterpretation in current research on liver fibrosis: the vessel in the center of CCl<sub>4</sub>-induced pseudolobules is a portal vein.
Hammad S., Braeuning A., Meyer C., Feza M., Hengstler J. G., Dooley S.
Arch Toxicol. 2017 Nov;91(11):3689-3692. doi: 10.1007/s00204-017-2040-8. Epub 2017 Aug 19. PMID: 28825120
Comprehensive Landscape of Nrf2 and p53 Pathway Activation Dynamics by Oxidative Stress and DNA Damage.
Hiemstra S., Niemeijer M., Koedoot E., Wink S., Klip J. E., Vlasveld M., de Zeeuw E., van Os B., White A., Water B. V.
Chem Res Toxicol. 2017 Apr 17;30(4):923-933. doi: 10.1021/acs.chemrestox.6b00322. Epub 2016 Dec 16. PMID: 27982581 [PubMed - indexed for MEDLINE]
Highlight report: 'Big data in the 3R's: outlook and recommendations', a roundtable summary.
Mahony C., Currie R., Daston G., Kleinstreuer N., van de Water B.
Arch Toxicol. 2018 Feb;92(2):1015-1020. doi: 10.1007/s00204-017-2145-0. Epub 2018 Jan 16. No abstract available. PMID: 29340744
Dynamic imaging of adaptive stress response pathway activation for prediction of drug induced liver injury.
Wink S., Hiemstra S. W., Huppelschoten S., Klip J. E., van de Water B.
Arch Toxicol. 2018 May;92(5):1797-1814. doi: 10.1007/s00204-018-2178-z. Epub 2018 Mar 3. PMID: 29502165
Ab initio chemical safety assessment: A workflow based on exposure considerations and non-animal methods.
Berggren E., White A., Ouedraogo G., Paini A., Richarz A. N., Bois F. Y., Exner T., Leite S., Grunsven L. A. V., Worth A., Mahony C.
Comput Toxicol. 2017 Nov;4:31-44. doi: 10.1016/j.comtox.2017.10.001. PMID: 29214231 [PubMed] Free PMC Article
Towards optimisation of induced pluripotent cell culture: Extracellular acidification results in growth arrest of iPSC prior to nutrient exhaustion.
Wilmes A., Rauch C., Carta G., Kern G., Meier F., Posch W., Wilflingseder D., Armstrong L., Lako M., Beilmann M., Gstraunthaler G., Jennings P.
Toxicol In Vitro. 2017 Dec;45(Pt 3):445-454. doi: 10.1016/j.tiv.2017.07.023. Epub 2017 Aug 15. PMID: 28821352 [PubMed - in process]
A snapshot on the progress of in vitro toxicology for safety assessment.
Jennings P., Corvi R., Culot M..
Toxicol In Vitro. 2017 Dec;45(Pt 3):269-271. doi: 10.1016/j.tiv.2017.10.024. No abstract available. PMID: 29195642 [PubMed - in process]
T. Luechtefeld, C. Rowlands and T. Hartung
Toxicol. Res., 2018, DOI: 10.1039/C8TX00051D
Alice Krebs, Johanna Nyffeler, Jörg Rahnenführer and Marcel Leist
Received: March 23, 2018; doi:10.14573/altex.1803231; ALTEX 35(2), 2018
Johannes Delp, Simon Gutbier, Stefanie Klima, Lisa Hoelting, Kevin Pinto-Gil, Jui-Hua Hsieh, Michael Aichem, Karsten Klein, Falk Schreiber, Raymond R. Tice, Manuel Pastor, Mamta Behl and Marcel Leist
January 21, 2018; doi:10.14573/altex.1712182; ALTEX 35(2), 2018
Lena Smirnova, Nicole Kleinstreuer, Raffaella Corvi, Andre Levchenko, Suzanne C. Fitzpatrick and Thomas Hartung
April 5, 2018; doi:10.14573/altex.180
Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity
Bal-Price A., Hogberg H.T., Crofton K.M., Daneshian M., FitzGerald R.E., Fritsche E., Heinonen T., Hougaard Bennekou S., Klima S., Piersma A.H., Sachana M., Shafer T.J., Terron A., Monnet-Tschudi F., Viviani B., Waldmann T., Westerink R.H.S., Wilks M.F., Witters H., Zurich M.G., Leist M.
ALTEX. 2018 Feb 23. doi: 10.14573/altex.1712081. [Epub ahead of print]
Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes
Fritsche E., Grandjean P., Crofton K.M., Aschner M., Goldberg A., Heinonen T., Hessel E.V.S., Hogberg H.T., Bennekou S.H., Lein P.J., Leist M., Mundy W.R., Paparella M., Piersma A.H., Sachana M., Schmuck G., Solecki R., Terron A., Monnet-Tschudi F., Wilks M.F., Witters H., Zurich M.G., Bal-Price A.
Toxicol Appl Pharmacol. 2018 Feb 12. pii: S0041-008X(18)30043-7. doi: 10.1016/j.taap.2018.02.004. [Epub ahead of print]
A high-throughput approach to identify specific neurotoxicants/ developmental toxicants in human neuronal cell function assays
Delp J., Gutbier S., Klima S., Hoelting L., Pinto-Gil K., Hsieh J.H., Aichem M., Klein K., Schreiber F., Tice R.R., Pastor M., Behl M., Leist M.
ALTEX. 2018 Jan 21. doi: 10.14573/altex.1712182. [Epub ahead of print]
Stage-specific metabolic features of differentiating neurons: Implications for toxicant sensitivity
Delp J., Gutbier S., Cerff M., Zasada C., Niedenführ S., Zhao L., Smirnova L., Hartung T., Borlinghaus H., Schreiber F., Bergemann J., Gätgens J., Beyss M., Azzouzi S., Waldmann T., Kempa S., Nöh K., Leist M.
Toxicol Appl Pharmacol. 2017 Dec 24. pii: S0041-008X(17)30494-5. doi: 10.1016/j.taap.2017.12.013. [Epub ahead of print]
An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition
Terron A., Bal-Price A., Paini A., Monnet-Tschudi F., Bennekou S.H.; EFSA WG EPI1 Members, Leist M., Schildknecht S.
Arch Toxicol. 2018 Jan;92(1):41-82. doi: 10.1007/s00204-017-2133-4. Epub 2017 Dec 5. Review.
A structure-activity relationship linking non-planar PCBs to functional deficits of neural crest cells: new roles for connexins
Nyffeler J., Chovancova P., Dolde X., Holzer A.K., Purvanov V., Kindinger I., Kerins A., Higton D., Silvester S., van Vugt-Lussenburg B.M.A., Glaab E., van der Burg B., Maclennan R., Legler D.F., Leist M.
Arch Toxicol. 2017 Nov 21. doi: 10.1007/s00204-017-2125-4. [Epub ahead of print]
New animal-free concepts and test methods for developmental toxicity and peripheral neurotoxicity
Leist M.
Altern Lab Anim. 2017 Nov;45(5):253-260.
Adverse outcome pathways: opportunities, limitations and open questions
Leist M., Ghallab A., Graepel R., Marchan R., Hassan R., Bennekou S.H., Limonciel A., Vinken M., Schildknecht S., Waldmann T., Danen E., van Ravenzwaay B., Kamp H., Gardner I., Godoy P., Bois F.Y., Braeuning A., Reif R., Oesch F., Drasdo D., Höhme S., Schwarz M., Hartung T., Braunbeck T., Beltman J., Vrieling H., Sanz F., Forsby A., Gadaleta D., Fisher C., Kelm J., Fluri D., Ecker G., Zdrazil B., Terron A., Jennings P., van der Burg B., Dooley S., Meijer A.H., Willighagen E., Martens M., Evelo C., Mombelli E., Taboureau O., Mantovani A., Hardy B., Koch B., Escher S., van Thriel C., Cadenas C., Kroese D., van de Water B., Hengstler J.G.
Arch Toxicol. 2017 Nov;91(11):3477-3505. doi: 10.1007/s00204-017-2045-3. Epub 2017 Oct 19.
Combination of multiple neural crest migration assays to identify environmental toxicants from a proof-of-concept chemical library
Nyffeler J., Dolde X., Krebs A., Pinto-Gil K., Pastor M., Behl M., Waldmann T., Leist M.
Arch Toxicol. 2017 Nov;91(11):3613-3632. doi: 10.1007/s00204-017-1977-y. Epub 2017 May 5.
Tipping Points and Endogenous Determinants of Nigrostriatal Degeneration by MPTP
Schildknecht S., Di Monte D.A., Pape R., Tieu K., Leist M.
Trends Pharmacol Sci. 2017 Jun;38(6):541-555. doi: 10.1016/j.tips.2017.03.010. Epub 2017 Apr 23. Review.
OECD/EFSA workshop on developmental neurotoxicity (DNT): The use of non-animal test methods for regulatory purposes
Fritsche E., Crofton K.M., Hernandez A.F., Hougaard Bennekou S., Leist M., Bal-Price A., Reaves E., Wilks M.F., Terron A., Solecki R., Sachana M., Gourmelon A.
ALTEX. 2017;34(2):311-315. doi: 10.14573/altex.1701171. No abstract available.
Impairment of human neural crest cell migration by prolonged exposure to interferon-beta
Pallocca G., Nyffeler J., Dolde X., Grinberg M., Gstraunthaler G., Waldmann T., Rahnenführer J., Sachinidis A., Leist M.
Arch Toxicol. 2017 Oct;91(10):3385-3402. doi: 10.1007/s00204-017-1966-1. Epub 2017 Apr 1.
Stem Cell Transcriptome Responses and Corresponding Biomarkers That Indicate the Transition from Adaptive Responses to Cytotoxicity
Waldmann T., Grinberg M., König A., Rempel E., Schildknecht S., Henry M., Holzer A.K., Dreser N., Shinde V., Sachinidis A., Rahnenführer J., Hengstler J.G., Leist M.
Chem Res Toxicol. 2017 Apr 17;30(4):905-922. doi: 10.1021/acs.chemrestox.6b00259. Epub 2016 Dec 21.
Hybrid optimal descriptors as a tool to predict skin sensitization in accordance to OECD principles
A. P. Toropova, A. A. Toropov
Toxicology Letters 275 (2017) 57–66
The index of ideality of correlation: A criterion of predictability of QSAR models for skin permeability?
A. P. Toropova, A. A. Toropov
Science of the Total Environment 586 (2017) 466–472
The application of new HARD-descriptor available from the CORAL software to building up NOAEL models
A. P. Toropova, A. A. Toropov, M. Marzo, S. E. Escher, J. L. Dorne, N. Georgiadis, E. Benfenati
Food and Chemical Toxicology xxx (2017) 1-7
The index of ideality of correlation: A criterion of predictive potential of QSPR/QSAR models?
A. A. Toropov, A. P. Toropova
Mutat Res Gen Tox En 819 (2017) 31–37
CORAL: Binary classifications (active/inactive) for drug-induced liver injury
A. P. Toropova, A. A. Toropov
Toxicology Letters 268 (2017) 51–57
Human environmental disease network: A computational model to assess toxicology of contaminants
O. Taboureau and K. Audouze
Altex, published October 21, 2016
In Silico Systems Pharmacology to Assess Drug's Therapeutic and Toxic Effects
A. Aguayo-Orozco; K. Audouze; S. Brunak; O. Taboureau
Current Pharmaceutical Design, Volume 22, Number 46, December 2016, pp. 6895-6902(8) - DOI: 10.2174/1381612822666160907093215
The ascending pathophysiology of cholestatic liver disease
P.L. Jansen, A Ghallab, N. Vartak, R. Reif, F.G. Schaap, J. Hampe, J.G. Hengstler
Hepatology. 2017 Feb;65(2):722-738
In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities
B. Z. Schmidt, M. Lehmann, S. Gutbier, E. Nembo, S. Noel, L. Smirnova, A. Forsby, J. Hescheler, H. X. Avci, T. Hartung, M. Leist, J. Kobolák, A. Dinnyés
January 2017 - Arch Toxicol - DOI: 10.1007/s00204-016-1805-9
Improved building up a model of toxicity towards Pimephales promelas by the Monte Carlo method
A. P. Toropovaa, A. A. Toropova, M. Raskovab, I. Raska
November 2016 - Environmental Toxicology and Pharmacology 48 (2016) 278–285
A Multi-Compartment Liver Model for the Prediction of Toxicokinetics
C. Fisher, O. Hatley, I. Gardner, M. Jamei
September 2016 - Toxicology Letters 258S (2016) S62–S324
Unraveling cellular pathways contributing to drug-induced liver injury by dynamical modeling
I.A. Kuijper, H. Yang, B. Van De Water, J.B. Beltman
Expert Opin Drug Metab Toxicol. 2016 Sep 23:1-13 - DOI:10.1080/17425255.2017.1234607
A. Chandrasekaran, H. X. Avci1, M. Leist, J. Kobolak and A. Dinnyes
September 2016 - Front. Cell. Neurosci. 10:215. doi:10.3389/fncel.2016.00215
Good Cell Culture Practice for Stem Cells and Stem-Cell-Derived Models
D. Pamies, A. Bal-Price, A. Simeonov, D. Tagle, D. Allen, D. Gerhold, D. Yin, F. Pistollato, T. Inutsuka, K. Sullivan, G. Stacey, H. Salem, M. Leist, M. Daneshian, M.C. Vemuri, R. McFarland, S. Coecke, S. C. Fitzpatrick, U. Lakshmipathy, A. Mack, W. Bo Wang, D. Yamazaki, Y. Sekino, Y. Kanda, L. Smirnova and T. Hartung
August 2016 - ALTEX 34(1), 2017 - 10.14573/altex.1607121
Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use
M. Aschner, S.Ceccatelli, M. Daneshian, E. Fritsche, N. Hasiwa, T. Hartung, H. T. Hogberg, M. Leist, A. Li, W.R. Mundy, S. Padilla, A. H. Piersma, A. Bal-Price, A. Seiler, R. Westerink , B. Zimmer, P. Lein
July 2016 - DOI: 10.14573/altex.1604201
V. Shinde, L. Hoelting, S. P. Srinivasan, J. Meisig, K. Meganathan, S. Jagtap, M. Grinberg, J. Liebing, N. Bluethgen, J. Rahnenführer, E. Rempel, R. Stoeber, S. Schildknecht, S. Förster, P. Godoy, C. van Thriel, J. A. Gaspar, J. Hescheler, T. Waldmann, J. Hengstler, M. Leist, A. Sachinidis
May 2016 - Arch Toxicol - DOI 10.1007/s00204-016-1741-8
M. Daneshian, H. Kamp, J. Hengstler, M. Leist, B. van de Water
March 2016 - Arch Toxicol - DOI 10.1007/s00204-016-1698-7
N. Ball, M. T. D. Cronin, J. Shen, K. Blackburn, E. D. Booth, M. Bouhifd, E. Donley, L. Egnash, C. Hastings, D. R. Juberg, A. Kleensang, N. Kleinstreuer, E. D. Kroese, A. C. Lee, T. Luechtefeld, A. Maertens, S. Marty, J. M. Naciff, J. Palmer, D. Pamies, M. Penman, A.N. Richarz, D. P. Russo, S. B. Stuard, G. Patlewicz, B. van Ravenzwaay, S. Wu, H. Zhu and T. Hartung
ALTEX 33(2), 2016
